Equimolar ratios of both heated at 145 deg c for 4 hrs and then the oil titurated in DCM , Dried over sodium sulphate , evapn gives oil , used as such for next step. is a method of protection of amino gp
2-[(1R)-2-Hydroxy-1-phenylethyl]-1H-isoindole-1,3(2H)-dione
205380-30-9 cas no
SpectralData
1H NMR (400 MHz, 298 K, CDCl3) δH 7.83 – 7.74 (2H, m, Pht), 7.70 – 7.60 (2H, m, Pht), 7.49 (2H, d, 3JHH = 7.4 Hz, Ph), 7.41 – 7.23 (3H, m, Ph),
5.51 (1H, dd, 3JHH = 8.9 Hz, 3JHH = 5.0 Hz, CH),
4.76 – 4.66 (1H, m, CH2),
4.24 (1H, dd, 3JHH = 11.4 Hz, 4JHH = 4.9 Hz, CH2),
3.47 (1H, s, OH).
13C NMR (100 MHz, 298 K, CDCl3) δC 168.89 (C=O),
136.88, 134.08 (Pht), 131.72, 128.70, 128.13, 127.97 (Ph), 123.31 (Pht),
61.98 (CH2), 57.46 (CH).
MS (ESI+) m/z 290.1 ([M+Na]+)
IR (cm-1) ν 3457, 1772, 1700, 1611, 1585, 1495, 1467, 1388, 1358, 1332, 1288, 1266, 1185, 1172, 1120, 1065, 1040, 1013, 999, 962, 919, 877, 838, 793, 765, 719, 698.
M. D. Chen, M. Z. He, X. Zhou, L. Q. Huang, Y. P. Ruan and P. Q. Huang, Tetrahedron, 2005, 61, 1335-1344http://dx.doi.org/10.1016/j.tet.2004.10.109
Aguilar, Nuria; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Synthesis, 1998 , 3, p. 313 - 316
Synthesis, 1998 , 3, p. 313 - 316