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Showing posts with label 6-dihydroxypyrimidine. Show all posts
Showing posts with label 6-dihydroxypyrimidine. Show all posts

Friday, 1 January 2016

5-Fluoro-4,6-dihydroxypyrimidine




5-Fluoro-4,6-dihydroxypyrimidine

 

 

 

 

Formamidine acetate (2.06 g, 20 mmol) was added to the solution of sodium (1.38 g, 60 mmol) in anhydrous ethanol (40 mL) and the mixture was heated to reflux. Diethyl 2-fluoromalonate (3.20 g, 18 mmol) was added dropwise over 20 minutes and the mixture was heated at reflux for 6 h. After cooling to room temperature, the solution was evaporated to dryness, the residue was dissolved in water (20 mL), acidified with HCl (5 mL), the precipitate was filtered, washed with water (5 mL), ethanol (2 × 5 mL) and diethyl ether (2 × 5 mL). After drying in vacuo, 5-fluoro-4,6-dihydroxypyrimidine (1.50 g, 64%) was obtained as a brown powder.

m.p.: >300 °C; ([M + H]+, 131.0244, C4H4FN2O2 requires: [M]+, 131.0257);

IR (neat, cm−1) 3053, 2639, 1633, 1547, 1388, 1213;

δH (DMSO d6, 400 MHz) 7.90 (1H, s, C–H), 12.38 (2H, bs, OH); δF (DMSO d6, 376 MHz): – 178.06 (s);  

δC (DMSO d6, 100 MHz) 132.79 (d, 1JCF 235.6, C–F), 144.46 (d, 4JCF 7.7, C–H), 155.83 (d, 2JCF 15.0, C–OH);  

m/z (ASAP) 131 (100%, [M + H]+).
 H. Weintritt, U. Stelzer, H. Gayer and W. Hubsch, US20030092723, 2003

 http://pubs.rsc.org/en/content/articlehtml/2015/gc/c5gc00402k





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Trobriand Island

Trobriand Islands - Wikipedia, the free encyclopedia

en.wikipedia.org/wiki/Trobriand_Islands
The Trobriand Islands are a 450 km² archipelago of coral atolls off the eastern coast of New Guinea. They are part of the nation of Papua New Guinea and are ...
Carrying cash: Along with yams, dried banana leaves are currency on the island. According to Lafforgue, this little girl's leaves are the equivalent of a bundle of £10 notes
Chief: Mr Tolobuwa is the head of Vaikiki village and always carries betel nuts, lime gourds and spatulas. The spatula is made from bird bone but human used to be used
Pretty: Little girls wear beautiful crowns of flowers and sea turtle shell earrings, some inherited from their mothers.
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Mourning: In the Trobriand Islands, those who have had a death in the family, such as this widow, shave their heads
Traditional: Trobriand Islanders wear red grass skirts unique to the islands for ceremonies and weddings. Completing the look are traditional feathered headbands
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Traditional: Trobriand Islanders wear red grass skirts unique to the islands for ceremonies and weddings. Completing the look are traditional feathered headbands
In charge: Girls are encouraged to take part in 'battles' and dance topless, with most choosing to wear red grass skirts, shells, feathers and fresh flowers
Elaborate: The skirts worn by the women are made from dried grass, while necklaces and bracelets are made from shells. Men wear cockatoo feather headdresses
Colourful: A woman from the Trobriand Islands
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Love shack: Each village has a special hut for teenagers who want to make love to their boyfriends and girlfriends - the doors are plastered with safe sex stickers
He was followed in the 1930s by a Catholic Mission but the islanders, although ruled by first the British and then the Australians, clung firm to their traditional ways.
Modernity: As more and more children go to school, some of the old ways are being lost
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Tradition: Other parts of Trobriand society, such as annual shell selling expeditions, continue
Chief's family: The house of the chieftain is recognisable by its height, shell decorations and the presence of a malagan - a carved, painted totem pole
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Chief's family: The house of the chieftain is recognisable by its height, shell decorations and the presence of a malagan - a carved, painted totem pole
Relaxed: While the islanders have tried hard to cling to their traditions, some have embraced parts of modern life such as instruments
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Pet: Pigs are eaten but they are considered to be pets and are treated like dogs
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Changing times: Although some modern items such as musical instruments have been embraced, islanders cling to many traditions, including keeping pigs as pets
Is that a googly? Cricket is hugely popular and was introduced by colonial authorities. Banned from going to war, the Trobriand Islanders settle their differences with a game
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Is that a googly? Cricket is hugely popular and was introduced by colonial authorities. Banned from going to war, the islanders settle their differences with a game
Home sweet home: In Obweria village, the many thatched huts are built on stilts around a central square, which is known to locals as the Buka
Big dreams: Seven-year-old Salome hopes to one day become a teacher
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Magic: According to the Trobriand Islanders, conception isn't linked to sex but instead to magic
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Magic: Although many, among them seven-year-old Salome, go to school, the Trobriand Islanders continue to believe in magic and believe it is responsible for conception
Important: Because yams are the main sign of wealth, yam houses - huts where the tubers are stored - are very important. Those belonging to chiefs are highly decorated
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Important: Because yams are a sign of wealth, yam houses - huts where the tubers are stored - are very important. Those belonging to chiefs are highly decorated
Pretty: Teenagers wear earrings made from tortoiseshell - keeping them in until they have a daughter of their own
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Fragile: One of the beautifully decorated kula boats, which comne covered in shells
Delicate: Teenage girls wear tortoiseshell earrings which they eventually pass on to their daughters, while traditional kula boats come covered in cowrie shells
Jewellery: Most of the Trobriand Islanders sport elaborate bracelets and necklaces, all of which are made from natural materials such as shells, stones and feathers
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Jewellery: Most of the Trobriand Islanders sport elaborate bracelets and necklaces, all of which are made from natural materials such as shells, stones and feathers
Rare: Because the islands are coral atolls, anything made from stone is considered rare and valuable. This stone was polished and given as a wedding gift
Rare: Because the islands are coral atolls, anything made from stone is considered rare and valuable. This stone was polished and given as a wedding gift
Excitement: The weekly flight from Port Moresby, capital of Papua New Guinea, is the most exciting moment of the week for many and draws huge crowds
Excitement: The weekly flight from Port Moresby, capital of Papua New Guinea, is the most exciting moment of the week for many and draws huge crowds
War: During World War II, thousands of American soldiers were stationed on the Trobriand Islands. Vintage dog tags and other memorabilia can be picked up for as little as 20p
War: During World War II, thousands of American soldiers were stationed on the Trobriand Islands. Vintage dog tags can be picked up for as little as 20p
Remote: The idyllic islands are home to the Trobriand Islanders, who still live in much the same way as they always have - including fishing from wooden canoes
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Remote: The idyllic islands are home to the Trobriand Islanders, who still live in much the same way as they always have - including fishing from wooden canoes
Paradise: The remote Trobriand Islands are a tiny knot of coral atolls sitting within the Solomon Sea and are part of Papua New Guinea
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