5-Fluoro-4,6-dihydroxypyrimidine
Formamidine acetate (2.06 g, 20 mmol) was added to the solution of sodium (1.38 g, 60 mmol) in anhydrous ethanol (40 mL) and the mixture was heated to reflux. Diethyl 2-fluoromalonate (3.20 g, 18 mmol) was added dropwise over 20 minutes and the mixture was heated at reflux for 6 h. After cooling to room temperature, the solution was evaporated to dryness, the residue was dissolved in water (20 mL), acidified with HCl (5 mL), the precipitate was filtered, washed with water (5 mL), ethanol (2 × 5 mL) and diethyl ether (2 × 5 mL). After drying in vacuo, 5-fluoro-4,6-dihydroxypyrimidine (1.50 g, 64%) was obtained as a brown powder.
m.p.: >300 °C; ([M + H]+, 131.0244, C4H4FN2O2 requires: [M]+, 131.0257);
IR (neat, cm−1) 3053, 2639, 1633, 1547, 1388, 1213;
δH (DMSO d6, 400 MHz) 7.90 (1H, s, C–H), 12.38 (2H, bs, OH); δF (DMSO d6, 376 MHz): – 178.06 (s);
δC (DMSO d6, 100 MHz) 132.79 (d, 1JCF 235.6, C–F), 144.46 (d, 4JCF 7.7, C–H), 155.83 (d, 2JCF 15.0, C–OH);
m/z (ASAP) 131 (100%, [M + H]+).
H. Weintritt, U. Stelzer, H. Gayer and W. Hubsch, US20030092723, 2003
http://pubs.rsc.org/en/content/articlehtml/2015/gc/c5gc00402k
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Trobriand Island
Trobriand Islands - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Trobriand_Islands
The Trobriand Islands are a 450 km² archipelago of coral atolls
off the eastern coast of New Guinea. They are part of the nation of
Papua New Guinea and are ...
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Traditional: Trobriand Islanders wear red grass skirts unique to the
islands for ceremonies and weddings. Completing the look are traditional
feathered headbands
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He was followed in the 1930s by a Catholic Mission but the islanders,
although ruled by first the British and then the Australians, clung firm
to their traditional ways.
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Chief's family: The house of the chieftain is recognisable by its
height, shell decorations and the presence of a malagan - a carved,
painted totem pole
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Changing times: Although some modern items such as musical instruments
have been embraced, islanders cling to many traditions, including
keeping pigs as pets
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Is that a googly? Cricket is hugely popular and was introduced by
colonial authorities. Banned from going to war, the islanders settle
their differences with a game
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Magic: Although many, among them seven-year-old Salome, go to school,
the Trobriand Islanders continue to believe in magic and believe it is
responsible for conception
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Important: Because yams are a sign of wealth, yam houses - huts where
the tubers are stored - are very important. Those belonging to chiefs
are highly decorated
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Delicate: Teenage girls wear tortoiseshell earrings which they
eventually pass on to their daughters, while traditional kula boats come
covered in cowrie shells
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Jewellery: Most of the Trobriand Islanders sport elaborate bracelets and
necklaces, all of which are made from natural materials such as shells,
stones and feathers
Rare: Because the islands are coral atolls, anything made from stone is
considered rare and valuable. This stone was polished and given as a
wedding gift
Excitement: The weekly flight from Port Moresby, capital of Papua New
Guinea, is the most exciting moment of the week for many and draws huge
crowds
War: During World War II, thousands of American soldiers were stationed
on the Trobriand Islands. Vintage dog tags can be picked up for as
little as 20p
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Remote: The idyllic islands are home to the Trobriand Islanders, who
still live in much the same way as they always have - including fishing
from wooden canoes
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