Methyl 3-Morpholino-3-oxo-2-(6-oxo-1-(pyridin-2-yl)-1,6-dihydropyridin-2-yl)propanoate (3k)
Pale yellow solid, 32.8 mg (92%);
1H NMR (600 MHz, CDCl3) δ 8.64 (ddd, J = 4.9, 2, 0.9 Hz, 1H), 7.89 (td, J = 7.7, 2.0 Hz, 1H), 7.48–7.39 (m, 2H), 7.34–7.28 (m, 1H), 6.67 (dd, J = 9.4, 1.2 Hz, 1H), 6.27 (dd, J = 7.0, 1.2 Hz, 1H), 4.60 (s, 1H), 3.70 (m, 2H), 3.67–3.57 (m, 5H), 3.54–3.44 (m, 2H), 3.42–3.28 (m, 2H);
13C NMR (150 MHz, CDCl3) δ 166.9, 164.4, 163.3, 151.1, 150.1, 140.4, 139.9, 139, 125, 124.8, 121.8, 107.1, 66.6, 66.3, 53.7, 53.2, 46.7, 42.8;
FT-IR: ν̃ = 3040, 2946.5, 2858.8, 1742.9, 1651.9, 1598, 1547, 1436, 1253 cm–1;
HRMS: calculated for [M + H]+C18H20N3O5: 358.1403, found 358.1407.
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Pale yellow solid, 32.8 mg (92%);
1H NMR (600 MHz, CDCl3) δ 8.64 (ddd, J = 4.9, 2, 0.9 Hz, 1H), 7.89 (td, J = 7.7, 2.0 Hz, 1H), 7.48–7.39 (m, 2H), 7.34–7.28 (m, 1H), 6.67 (dd, J = 9.4, 1.2 Hz, 1H), 6.27 (dd, J = 7.0, 1.2 Hz, 1H), 4.60 (s, 1H), 3.70 (m, 2H), 3.67–3.57 (m, 5H), 3.54–3.44 (m, 2H), 3.42–3.28 (m, 2H);
13C NMR (150 MHz, CDCl3) δ 166.9, 164.4, 163.3, 151.1, 150.1, 140.4, 139.9, 139, 125, 124.8, 121.8, 107.1, 66.6, 66.3, 53.7, 53.2, 46.7, 42.8;
FT-IR: ν̃ = 3040, 2946.5, 2858.8, 1742.9, 1651.9, 1598, 1547, 1436, 1253 cm–1;
HRMS: calculated for [M + H]+C18H20N3O5: 358.1403, found 358.1407.
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