Bicyclo[1.1.1]penta
177287-49-9
[RN]
22287-35-0
[RN]
Bicyclo[1.1.1]penta
Org Lett. 2014 Apr 4;16(7):1884-7. doi: 10.1021/ol500635p. Epub 2014 Mar 14.
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.
http://pubs.acs.org/doi/abs/10.1021/ol500635p
Abstract
From
a medicinal chemistry perspective, bicyclo[1.1.1]pentan-1-amine (1) has
served as a unique and important moiety. Synthetically, however, this
compound has received little attention, and only one scalable route to
this amine has been demonstrated. Reduction of an easily available and
potentially versatile intermediate, 1-azido-3-iodobicyclo[1.1.1]pentane
(2), can offer both a flexible and scalable alternative to this target.
Herein, we describe our scrutiny of this reportedly elusive
transformation and report our ensuing success with this endeavor.
- See more at: http://organicsynthesisinternational.blogspot.in/#sthash.ZJXPNU5S.dpuf
Org Lett. 2014 Apr 4;16(7):1884-7. doi: 10.1021/ol500635p. Epub 2014 Mar 14.
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.
http://pubs.acs.org/doi/abs/10.1021/ol500635p
Abstract
From
a medicinal chemistry perspective, bicyclo[1.1.1]pentan-1-amine (1) has
served as a unique and important moiety. Synthetically, however, this
compound has received little attention, and only one scalable route to
this amine has been demonstrated. Reduction of an easily available and
potentially versatile intermediate, 1-azido-3-iodobicyclo[1.1.1]pentane
(2), can offer both a flexible and scalable alternative to this target.
Herein, we describe our scrutiny of this reportedly elusive
transformation and report our ensuing success with this endeavor.
- See more at: http://organicsynthesisinternational.blogspot.in/#sthash.ZJXPNU5S.dpuf
Org Lett. 2014 Apr 4;16(7):1884-7. doi: 10.1021/ol500635p. Epub 2014 Mar 14.
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.
http://pubs.acs.org/doi/abs/10.1021/ol500635p
http://pubs.acs.org/doi/suppl/10.1021/ol500635p/suppl_file/ol500635p_si_001.pdf
Abstract
From
a medicinal chemistry perspective, bicyclo[1.1.1]pentan-1-amine (1) has
served as a unique and important moiety. Synthetically, however, this
compound has received little attention, and only one scalable route to
this amine has been demonstrated. Reduction of an easily available and
potentially versatile intermediate, 1-azido-3-iodobicyclo[1.1.1]pentane
(2), can offer both a flexible and scalable alternative to this target.
Herein, we describe our scrutiny of this reportedly elusive
transformation and report our ensuing success with this endeavor.
Org Lett. 2014 Apr 4;16(7):1884-7. doi: 10.1021/ol500635p. Epub 2014 Mar 14.
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.
http://pubs.acs.org/doi/abs/10.1021/ol500635p
Abstract
From
a medicinal chemistry perspective, bicyclo[1.1.1]pentan-1-amine (1) has
served as a unique and important moiety. Synthetically, however, this
compound has received little attention, and only one scalable route to
this amine has been demonstrated. Reduction of an easily available and
potentially versatile intermediate, 1-azido-3-iodobicyclo[1.1.1]pentane
(2), can offer both a flexible and scalable alternative to this target.
Herein, we describe our scrutiny of this reportedly elusive
transformation and report our ensuing success with this endeavor.
- See more at: http://organicsynthesisinternational.blogspot.in/#sthash.ZJXPNU5S.dpuf
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE
Join me on twitter
Join me on google plus 
Googleplus
Googleplus
amcrasto@gmail.com
SRILANKAN FOOD
What Is Sri Lankan Food Anyway?
Hoppers at San Rasa.
Sri Lanka is a small island off the Indian subcontinent, and its
cuisine bears similarities to those of both northern and southern India.
Describing Sri Lankan food in full demands an article of its own, but
here's a brief take on what you can expect to find on Staten Island.Saucy curries are staples, often enriched with coconut milk and a spice mixture that might veer towards spicy, pungent, or sweet. The curries (meat, fish, and vegetarian) come with rice and vegetable sides like bitter melon and string beans.
Some dishes are composed of starchy mains with strong sauces and relishes on the side. The most famous of these are hoppers, fermented rice flour batter cooked in dome-shaped molds, then stacked up with an egg set in one. String hoppers are nests of rice flour noodles that are steamed and often sold in large quantities; pithu is a log of rice steamed with shredded coconut—the good ones are nutty-sweet and a little bouncy. All of these items can be eaten by hand, with sauces used for dipping.
There are also snacks sometimes called "short eats": fried lentil cakes similar to spiced Indian vadai (savory doughnuts), several types of roti, and fried vegetable and fish cutlets. A more substantial item, and one of my favorites: kotthu, chopped up starch—string hoppers or roti typically—stir fried with aromatic vegetables, egg, spices, and sometimes meat. Stir fried meats are sometimes called devilled, meaning they come in a sweet and spicy sauce not unlike some Chinese dishes.
Lamprie at San Rasa.
///////
No comments:
Post a Comment