1-Methyl-3-methylenepyrrolidin-2-one

paper

Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes

Mingyang Fu, Long Chen, Yongpeng Jiang, Zhong-Xing Jiang^*, and Zhigang Yang^*

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China

Org. Lett., Article ASAP

DOI: 10.1021/acs.orglett.5b03080

Publication Date (Web): January 11, 2016

Copyright © 2016 American Chemical Society

*E-mail: zxjiang@whu.edu.cn., *E-mail: zgyang@whu.edu.cn.

A highly practical copper-catalyzed intermolecular halotrifluoromethylation of alkenes has been developed under mild reaction conditions. A variety of Cl/Br-containing trifluoromethyl derivatives were directly synthesized from a wide range of alkenes, including electron-deficient and unactivated alkenes.

 http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b03080

 see...........http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.5b03080/suppl_file/ol5b03080_si_002.pdf









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