Ethyl 4-hydroxy-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC00157B, Paper

Hamideh Ahankar, Ali Ramazani, Katarzyna Slepokura, Tadeusz Lis, Sang Woo Joo
In this study, we reported a simple and efficient route for the one-pot sonochemical synthesis of substituted 3-pyrrolin-2-ones by citric acid as an additive.

Synthesis of pyrrolidinone derivatives from aniline, an aldehyde and diethyl acetylenedicarboxylate in an ethanolic citric acid solution under ultrasound irradiation

The ultrasound-promoted one-pot multicomponent synthesis of substituted 3-pyrrolin-2-ones using citric acid as a green additive in a green solvent is reported. Citric acid catalyzed the reaction efficiently without the need for any other harmful organic reagents. Clean reaction profile, easy work-up procedure, excellent yields and short reaction times are some remarkable features of this method. The utilization of ultrasound irradiation makes this method potentially very useful, fast, clean and convenient.

Synthesis of pyrrolidinone derivatives from aniline, an aldehyde and diethyl acetylenedicarboxylate in an ethanolic citric acid solution under ultrasound irradiation

Hamideh Ahankar,^a   Ali Ramazani,*^a   Katarzyna Ślepokura,^b  Tadeusz Lis^b and   Sang Woo Joo*^c  

*Corresponding authors

^aDepartment of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran
E-mail: aliramazani@gmail.com

^bFaculty of Chemistry, University of Wrocław, 14 Joliot-Curie St., 50-383 Wrocław, Poland

^cSchool of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea
E-mail: swjoo@yu.ac.kr

Green Chem., 2016, Advance Article

http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00157B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract
DOI: 10.1039/C6GC00157B

Ethyl 4-hydroxy-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrrole-3-carboxylate 

ethyl 4-hydroxy-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

//////Synthesis, pyrrolidinone derivatives, aniline,  aldehyde,  diethyl acetylenedicarboxylate,  ethanolic citric acid solution,  ultrasound irradiation

Dream beach, Hong Island, Thailand,  

koh hong, KRABI

 

 

 


 

 

 
 


//////

ML404 (KSC-392-065)

ML404

¹H NMR Spectrum (400 MHz, Acetone-d₆) of the Probe CID72199308, KSC-392-065

¹³C NMR (101 MHz, Acetone-d₆) δ 172.82, 160.59, 159.11, 158.03, 151.30, 137.76, 132.82, 132.07, 131.58, 130.67, 128.96, 126.42, 124.48, 119.08, 118.30, 113.52, 100.39, 17.49.

 HRMS calcd for (C₁₇H₁₃ClN₂O₃ −[H])^–: 327.0542, found: 327.0538.


 


 ML404(KSC-392-065)

 N-(5-chloro-2-methylphenyl)-5-(3-hydroxyphenyl)isoxazole-3-carboxamide (55 mg, 0.167 mmol, 43 % yield) as a white solid.  



¹H NMR (400 MHz, Acetone-d₆) δ 9.19 (s, 1H), 7.95 (d, J = 2.3 Hz, 1H), 7.50–7.37 (m, 3H), 7.32 (d, J = 8.2 Hz, 1H), 7.23 (s, 1H), 7.19 (dd, J = 8.2, 2.3 Hz, 1H), 7.03 (ddd, J = 7.9, 2.4, 1.2 Hz, 1H), 2.38 (s, 3H).  



¹³C NMR (101 MHz, Acetone-d₆) δ 172.82, 160.59, 159.11, 158.03, 137.76, 132.82, 132.07, 131.58, 130.67, 128.96, 126.42, 124.48, 119.08, 118.30, 113.52, 100.39, 17.49.


HRMS (ESI^–) m/z calcd for (C17H13ClN2O3 −[H])^–: 327.0542, found: 327.0538.


UPLC purity at 214 nm is 99%.

 

Best street food cities in Asia

Asia is famous for its impossibly delicious street food, but which cities should be on your culinary bucket list? From must-eat dishes to iconic night markets, here is Skyscanner’s guide to Asia’s best street food cities. Hungry yet?

1. Hanoi, Vietnam

Hanoi’s Old Quarter is a foodie paradise, with hundreds of colourful stalls overflowing into a maze of streets. As you eat your way through this vibrant neighbourhood, here are some delicacies to look out for. Tucking into a steaming bowl of beef or chicken pho is a quintessential Hanoi experience; but the real hero of street food isbun cha, a heavenly dish of barbecued pork served with rice noodles and fragrant fish sauce. Another decadent snack is nem cua be – crispy spring rolls stuffed with delicious crabmeat. After feasting like a king, don’t forget to indulge in Hanoi’s most exquisite treat: iced coffee with sweetened condensed milk, also known as ca phe sua da.
 
Read more: 7 ideas for the 7 Singapore long weekends this 2015

Eating on the sidewalk is a Hanoi tradition. Photo credit: Paul Galow / Flickr

Photo credit: Paul Galow

2. Bangkok, Thailand

Bangkok is famous for its dizzying array of delectable street food, so where do you even start? If you’re a newbie, head to Sukhumvit Soi 38, a bustling road that offers the perfect introduction to Bangkok’s eclectic food scene. You can’t go wrong with pad see ew, a sinfully tasty dish of stir-fried noodles, dark soy sauce, and scrambled egg; or how about snacking on grilled pork skewers marinated in coconut milk (moo ping)?
For dessert, gorge on banana fritters, luscious mangosteens, or the ubiquitous mango sticky rice. Avid eaters should continue their food adventures at Yaowarat (Bangkok’s Chinatown), Banglamphu and Wang Lang Market. Warning: you might never leave.
 
Read more: Rediscover Bangkok in Instagram pictures

Dive into Bangkok's foodie paradise! Photo credit: Austronesian Expeditions / Flickr

Photo credit: Austronesian Expeditions

3. Penang, Malaysia

Penang is a melting pot of Chinese, Malay and Indian cultures, so it’s no wonder that it boasts some of the world’s best street food. Although you’re guaranteed to eat well in virtually every corner of Penang, the charming city of George Town is your gateway to hawker heaven. Don’t miss the iconic assam laksa, a tangy fish-based soup infused with tamarind and chilli, or the salty-sweet perfection of rojak. Other swoon-worthy dishes include curry noodles, roti canai, and Penang’s unbeatable version of char kway teow.
Overwhelmed by all this culinary goodness? Hop on one of George Town’s many street food tours for the ultimate sensory feast.
 
Read more: 6 best family hotels in Penang

Don't leave Penang without trying assam laksa! Photo credit: Daniel Chong Kah Fui / Flickr

4. Taipei, Taiwan

Exploring Taipei’s legendary night markets is like diving into a sea of rich flavours. From savoury oyster omelettes to grilled squid skewers, the street food scene is out of this world. Treat your taste buds to scrumptious pork belly buns (gua bao), or an epic bowl of braised beef noodles. And now for the real challenge: are you brave enough to try stinky tofu? If that potent snack is too much to handle, you can opt for another quirky Taiwanese specialty: deep-fried milk on a stick!
For a truly authentic experience, head to Raohe, Ningxia or Shilin night markets. Is there anything better than noshing on gloriously cheap food until the wee hours of morning?
 
Read more: 9 best things to do in Taipei

It's skewers galore at Taipei's night markets! Photo credit: Aaron Shumaker / Flickr

Photo credit: Aaron Shumaker

5. Fukuoka, Japan

Fukuoka should be on every serious foodie’s list, if only for its famously divine tonkotsu ramen. When you try this mouth-watering combination of silky noodles and creamy pork-based broth, you just might shed tears of joy. Fukuoka is known for its myriad of lively open-air food stalls that only open at dusk. These yatai act as pop-up restaurants, serving delicious fare like yakitori and tempura, along with generous doses of sake.
Although you’re likely to bump into a yatai at every turn, the best ones can be found in the districts of Tenjin and Nakasu. Don’t leave Fukuoka without tasting iwashi mentaiko – grilled Japanese sardines stuffed with spicy pollock roe. This is street food at its best.
 
Read more: 7 must-try cocktail bars in Asia Pacific

Experience Fukuoka's unique food stalls. Photo credit: drufisher / Flickr

  DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Join me on Linkedin

Join me on Facebook FACEBOOK

Join me on twitter     

Join me on google plus Googleplus

 amcrasto@gmail.com

 

/////////