Unravelling Glycobiology by NMR Spectroscopy

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 A) Structural representation of _D-glucose and its anomeric configurations (α- and β-forms) in aqueous solution. The numbers of the hydrogen and carbon atoms are indicated by digits, and the solvent exchangeable protons are red-colored. (B) ¹H- and (C) ¹³C-NMR 1D spectra, Bruker 400 MHz and 37^o C of _D-glucose in solution after waiting to reach the anomeric equilibrium (2 days as shown at Figure 1). The signals are labeled according to the atom numbers and anomeric forms designated in the molecules represented on panel A.

 http://www.intechopen.com/books/glycosylation/unravelling-glycobiology-by-nmr-spectroscopy


DACCA FOOD, BANGLADESH, DACCA

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ZIPRASIDONE

Ziprasidone

Ziprasidone

CAS 146939-27-7

CAS Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one

Additional Names: 5-(2-(4-(1,2-benzisothiazol-3-yl)piperazinyl)ethyl)-6-chlorooxindole

Manufacturers' Codes: CP-88059

Molecular Formula: C21H21ClN4OS

Molecular Weight: 412.94

Percent Composition: C 61.08%, H 5.13%, Cl 8.59%, N 13.57%, O 3.87%, S 7.77%

 

Hydrochloride monohydrate

CAS Registry Number: 138982-67-9; 122883-93-6 (anhydrous)

Manufacturers' Codes: CP-88059-1

Trademarks: Geodon (Pfizer); Zeldox (Pfizer)

Molecular Formula: C21H21ClN4OS.HCl.H2O

Molecular Weight: 467.41

Percent Composition: C 53.96%, H 5.18%, Cl 15.17%, N 11.99%, O 6.85%, S 6.86%

Literature References: Prepn: D. J. M. Allen et al., EP 586191; eidem, US 5312925 (1993, 1994 both to Pfizer).

Properties: White to slightly pink powder. Also prepd as the hemihydrate, mp >300°.

Melting point: mp >300°

 

Therap-Cat: Antipsychotic.

SEE.........http://newdrugapprovals.org/2013/11/19/ziprasidone/

 

Ziprasidone (marketed as Geodon, Zeldox by Pfizer) was the fifth atypical antipsychotic to gain approval (February 2001) in the United States. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia, and acute mania and mixed states associated withbipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate.

Ziprasidone is also used off-label for depression, bipolar maintenance, mood disorders, anxiety, aggression, dementia, attention deficit hyperactivity disorder, obsessive compulsive disorder, autism, and post-traumatic stress disorder.

Ziprasidone synthesis: John A. Lowe, Arthur A. Nagel. Pfizer Inc. U.S. Patent 4,831,031 (1989).

1H NMR PREDICT

13C NMR PREDICT

http://newdrugapprovals.org/2013/11/19/ziprasidone/

DACCA, BANGLADESH

Farmer Harvesting Jute, Tangail,Dhaka, Bangladesh Photographic Print

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