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Showing posts with label ZIPRASIDONE. Show all posts
Showing posts with label ZIPRASIDONE. Show all posts

Thursday 30 April 2015

ZIPRASIDONE


Ziprasidone3Dan.gif
Ziprasidone
Ziprasidone
CAS 146939-27-7
CAS Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one
Additional Names: 5-(2-(4-(1,2-benzisothiazol-3-yl)piperazinyl)ethyl)-6-chlorooxindole
Manufacturers' Codes: CP-88059
Molecular Formula: C21H21ClN4OS
Molecular Weight: 412.94
Percent Composition: C 61.08%, H 5.13%, Cl 8.59%, N 13.57%, O 3.87%, S 7.77%
 
Hydrochloride monohydrate
CAS Registry Number: 138982-67-9; 122883-93-6 (anhydrous)
Manufacturers' Codes: CP-88059-1
Trademarks: Geodon (Pfizer); Zeldox (Pfizer)
Molecular Formula: C21H21ClN4OS.HCl.H2O
Molecular Weight: 467.41
Percent Composition: C 53.96%, H 5.18%, Cl 15.17%, N 11.99%, O 6.85%, S 6.86%
Literature References: Prepn: D. J. M. Allen et al., EP 586191eidemUS 5312925 (1993, 1994 both to Pfizer).
Properties: White to slightly pink powder. Also prepd as the hemihydrate, mp >300°.
Melting point: mp >300°
 
Therap-Cat: Antipsychotic.
 
Ziprasidone (marketed as GeodonZeldox by Pfizer) was the fifth atypical antipsychotic to gain approval (February 2001) in the United States. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia, and acute mania and mixed states associated withbipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate.
Ziprasidone is also used off-label for depression, bipolar maintenance, mood disorders, anxiety, aggression, dementia, attention deficit hyperactivity disorderobsessive compulsive disorderautism, and post-traumatic stress disorder.

Ziprasidone synthesis: John A. Lowe, Arthur A. Nagel. Pfizer Inc. U.S. Patent 4,831,031 (1989).

1H NMR PREDICT
Ziprasidone mesilate NMR spectra analysis, Chemical CAS NO. 199191-69-0 NMR spectral analysis, Ziprasidone mesilate H-NMR spectrum
13C NMR PREDICT
Ziprasidone mesilate NMR spectra analysis, Chemical CAS NO. 199191-69-0 NMR spectral analysis, Ziprasidone mesilate C-NMR spectrum





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