DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label DR SRINIVASA REDDY. Show all posts
Showing posts with label DR SRINIVASA REDDY. Show all posts

Monday 14 December 2015

FIRST TOTAL SYNTHESIS OF HUNANAMYCIN A BY DR SRINIVASA REDDY, CSIR-NCL, PUNE, INDIA


Abstract Image


The first total synthesis of hunanamycin A, an antibiotic natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core from a marine-derived Bacillus hunanensis, is disclosed. The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration. In addition, four new analogues of the natural product are reported.


Read about author at 
 http://oneorganichemistoneday.blogspot.in/2015/02/dr-d-srinivasa-reddy.html



dr

 

Dr. Srinivasa Reddy

 

 

 

First Total Synthesis of Hunanamycin A

CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune, 411008, India
Org. Lett., 2013, 15 (17), pp 4556–4559
DOI: 10.1021/ol402110e
Publication Date (Web): August 21, 2013
Copyright © 2013 American Chemical Society
ds.reddy@ncl.res.in, †
Summer project student from Department of Chemistry, Pune University, Pune, India.
http://pubs.acs.org/doi/abs/10.1021/ol402110e
http://pubs.acs.org/doi/suppl/10.1021/ol402110e/suppl_file/ol402110e_si_001.pdf


HUNANAMYCIN A


SYNTHESIS CONSTRUCTION





 NEXT



















1H NMR




 13C NMR



HUNANAMYCIN A, smiles..............c21cc(c(c3c1N(C(C(N2C[C@@H](C(O)[C@@H](CO)O)O)=O)=O)CC[C@@]3(C)C)C)C




see also ...........................




Abstract Image


Hunanamycin A, the first natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

Hunanamycin A, an Antibiotic from a Marine-Derived Bacillus hunanensis

Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States
Org. Lett., 2013, 15 (2), pp 390–393
DOI: 10.1021/ol303376c
Publication Date (Web): January 10, 2013
Copyright © 2013 American Chemical Society

see
http://pubs.acs.org/doi/abs/10.1021/ol303376c
Hunanamycin A, an Antibiotic from a Marine-Derived Bacillus hunanensis. OL, 15(2):390- 393, 2013
                                    






I picked this up from
see................http://www.millersville.edu/chemistry/research/organic.php

Organic Chemistry Research

Janelle B

Studies Toward the Synthesis of Hunanamycin A and its Derivatives

Student Researcher: Janelle Biehl
Faculty Advisor: Dr. Steven Kennedy
The goal of this research is to synthesize Hunanamycin A from commercially available chemicals. Hunanamycin A is a natural product recently isolated from Bacillus hunanensis. It can kill the pathogens Salmonella and E. coli. Test reactions will be run on model systems to explore multiple ways of synthesizing the target product. From the complete synthesis further biological testing can be done to check for other antibacterial properties.

John N

Studies Toward the Synthesis of Hunanamycin A and its Derivatives

Student Researcher: John Noyes
Faculty Advisor: Dr. Steven Kennedy
Hunanamycin A (HA) has been found to have antibacterial properties for various pathogens such as Salmonella and E. coli. The goal of this research is to synthesize HA as well as other derivatives of HA for further biological studies. Emphasis will be placed on developing an efficient route to HA and discovering new derivatives of HA.


 see.................http://academic.ncl.res.in/ds.reddy/research
 
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PENANG, MALAYSIA
Map of penang



Georgetown beach on Penang island, northwest Malaysia






 



 At Kek Lok Si.

 

 

 

 
 Walk around — at Straits Quay.

 
 

 
at Water Fall Kebun Bunga Penang.


 

 
 

 


 

 Penang Laksa, No7 Most Delicious Food in the World by CNNGo


 
 Wow!! Look at the Christmas deco at Queensbay Mall!! Photo by Jennifer Cheah — at Queensbay Mall.

 

 
New Sri Sri Radha Krishna Temple in Penang, MALAYSIA



 

 

 

 
 

Thaipusam 2015
Date: 3 February 2015
Main venue: Arulmigu Balathandayuthapani Waterfall Temple

Thaipusam is a three-day festival celebrated during the full moon of the 10th month in the Hindu calendar and signifies the victory of good over evil. The celebration begins with a pilgrimage procession on the eve of Thaipusam to bring the statue of Lord Muruga on a silver chariot led by more than 60 ka... See More


 
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