An Improved Protocol for the Preparation of 3-Pyridyl- and Some Arylboronic Acids
Process
Research Department, Merck Research Laboratories, P.O. Box 2000,
Rahway, New Jersey 07065 wenjie_li@merck.com; dorian_nelson@merck.com
J. Org. Chem., 2002, 67 (15), pp 5394–5397
DOI: 10.1021/jo025792p
Publication Date (Web): June 13, 2002
Copyright © 2002 American Chemical Society
Abstract
3-Pyridylboronic
acid was prepared in high yield and bulk quantity from 3-bromopyridine
via a protocol of lithium−halogen exchange and “in situ quench”. This
technique was further studied and evaluated on other aryl halides in the
preparation of arylboronic acids.
paper
.
4 ............... tris(3-pyridyl)boroxin
Tris(3-pyridyl)boroxin:
Pyridine, 3,3',3"-(2,4,6-boroxintriyl)tris-; (160688-99-3)
compd4= The checkers obtained trispyridylboroxin in various hydration levels (0.85 - 1.0 H2O). A satisfactory melting point for this solid could not be obtained. 1H NMR pdf (400 MHz, CD3OD): δ 7.66 (br s, 1H), 8.38 (d, J=6.6, 1H), 8.51 (dd, J=1.2, 4.4, 1H), 8.61 (br s, 1 H). 1H NMR spectra were complicated in other solvents such as CDCl3 and DMSO-d6. Anal Calcd. for C15H12B3O3N3 · 1.0H2O: C, 54.15; H, 4.24; N, 12.63. Found: C, 53.95; H, 3.91; N, 12.35. Yield based on this formula is 85%. The submitters report obtaining the product in 91% yield.
GOA, INDIA,
Whether you’re a fan of relaxing brunches, fancy a quick snack in between shopping or just love a late afternoon cream tea, Goa has got the cafe to suit your mood. Just check out recommendations for a great treat out on your next Goa holiday.
1. Cafe Lovii, Margao
Welcome to the city’s latest secret, tucked in a hideaway just next
to Margao’s Old Judicial Court garden. Cafe Lovii’s selection of
healthy wraps, delicious sandwiches and nutritious shakes provide a
refreshing alternative to the city’s usual bustling eateries with poky
corners and packed tables for the lunch-time crowd. It’s a great place
for late brunch – try the quail eggs omelette and the delectable Fruit
Tower with lashings of yoghurt to top it off. You can get a filling meal
for under INR 200 here.
Have a refreshing shake at Cafe Lovii.
Photo credit: www.burrp.com
2. Urban Cafe, Panaji
Tucked away in Panjim’s Latin Quarter is this cosy, two floor
hide-out that has become the favourite hang-out for freelancers and solo
travellers.The ground floor space is light-filled and welcoming but you
can head upstairs for a cosier ambience with dim lights, dark walls and
bottomless sofas that suck you in and never want to let you go. This is
a great stopover for a cold coffee, a brownie and a long chat with your
best buddy. Pssst... There’s a magazine rack full of great reads. A drink and a brownie will cost you around INR 250.
After a coffee at the Urban Cafe, enjoy a stroll around Goa's famous Latin Quarter
3. Ruta's, Mapusa
If you’re dying for a decent cappuccino and sandwich in the area,
then Ruta’s is your best bet. Located next to FabIndia, it’s a great
stopover in between shopping. Try the Quesadilla if you’re in the mood
for melted cheese and don’t leave without trying the Sticky buns. You’ll
be craving it even after the last morsel is gone. Coffee and a main
dish will cost you about INR 600.
Pop by Ruta's if you're in the Mapusa area.
Photo credit: www.zomato.com
4. Baker's Studio, Baga
Craving a great morning fry-up that you don’t have to make
yourself? Then head over to Baker’s studio in Tito’s lane, Baga. It’s
great for taking the edge off those morning-after hangovers and sliding
slowly into your day after a hard night of Goa-style partying. Order a
lip-smacking British fry-up with fried eggs on toast, two slices of
bacon, sausage, beans, mushrooms and a slow-cooked tomato to top it off,
all for just INR 300.
This is the place to visit if you want tasty fuel for your busy morning.
Photo credit: www.whatsupgoa.com
5. Bodega, Panaji
If you’re looking for a quiet, artsy place with a bit of romance to
it (and free wifi), you can’t go wrong with Cantina Bodega set atop
Altinho. Lining the courtyard of Sunaparanta – Goa Centre for the Arts,
it’s the perfect place to go for a breezy catch-up with friends or a
comforting break after a hectic week. You can even drop in for a late
Sunday breakfast here with waffles, pancakes and even Eggs Benedict to
order. Or you can settle in for a pizza or fresh salad. Some say the red
velvet cupcakes are to die for! A meal costs roughly INR 600.
Read more: Best brunch places in Delhi
Head to Bodega if you like your coffee and snack with a side of art.
Photo credit: www.sgcfa.org
6. Cherry Tomato Cafe at Carpe Diem, Majorda
This little art cafe is buried in the heart of Majorda, deep in the
annals of a nineteenth century Portuguese mansion. The renovated old
place now houses Carpe Diem, an art centre that exhibits paintings and
holds workshops and creative events of all types. It also has one of the
best cafes in South Goa, with a smattering of tables in the little
garden at the back, surrounded by works of art on display. Order the
Boozy Banana shake as a starter and the Cubano pulled pork sandwich as a
follow-up for about INR 450 together. You’ll need a short nap after to
recover from your tasty meal!
Read more: 9 ways to explore cultural Goa
Enjoy the hip atmosphere around you while sip a delicious smoothie.
Photo credit: www.carpediemgoa.com
7. Lila Cafe, Anjuna
The thatched roof and bamboo chairs give it a picturesque, light,
airy setting and a real laid back feel to this little gem, located on
the Calangute-Arpora-Siolim road. Delicious, buttery croissant
sandwiches are the mouth-watering munchies to order here. But there’s
plenty of other food to tempt the palate with hot breakfasts, tempting
smoothies and finger-licking apple pie on the menu too. It’s the kind of
place to pick if you want somewhere quiet to read your latest novel or
want to meet up with friends for a good gossip session.
The welcoming entrance to Lila Cafe draws you in.
Photo credit: www.selectmyrestaurant.com
8. Cafe Chocolatti, Candolim
When you think of Cafe Chocolatti, think of ordering the cream tea
complete with home-made scones and fresh strawberry jam. The cafe is
nestled within a high walled garden, giving it a secluded feel where you
can just get away from the hustle and bustle for a few hours while you
grab a light lunch or a snack and a coffee. A spinach and mushroom
savoury crepe with a chocolate shake will cost just under INR 500.
Two words...Chocolate. Cake. Enough said?
9. Natti's Naturals, Arpora
This health food store has an organic cafe that all
health-conscious folks will love. You’ll find it on a quiet stretch
along the Anjuna-Calangute route. The outdoor cafe is decked in pastels
and white, reflecting the sense of calm and serenity that permeates the
entire property. The cafe adjoining the store serves salads, burgers,
gluten-free desserts and fresh fruit juices combining unique aromatic
flavours.
Read more: Goa’s best eco-resorts
Enjoy the minimalist chic decor and surroundings of Nattis Naturals.
10. Thirsty Bear, Panaji
Right on the Bambolim highway, just a stone’s throw from the Goa
Dental College, is the Thirsty Bear. It’s a great stop for a
waffle-with-ice-cream brunch, a luscious chocolate milk shake or a quick
thin crust pizza. But it is more the kind of place where you stop when
you’re in a bit of a rush but still want a tasty sit-down breakfast to
fuel you up for a busy day. And best of all...its open 24-hours a day! A
drink and a bite will cost you just under INR 500.
Read more: 8 unique things to do in Goa during the day
Pop by anytime into the Thirsty Bear for a tasty snack - day or night.
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