Picoxystrobin
1 as a white solid with 99% purity by HPLC (retention time: 9.1 min). mp 74–75 °C (lit. mp 73–74).
Worthington, P. A.; Munns, G. R.; Jones, R. V. H.; Standen, M. C. H.; Ritchie, D. J.; Forrester, J.Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl)phenylacetate. WO patent 9701538,1997; CAN 126:171489
1H NMR (CDCl3, 400 MHz): δ 3.57 (s, 3H), 3.68 (s, 3H), 5.25 (s, 2H), 6.78 (d, J = 8.4 Hz, 1H), 7.08–7.14 (m, 2H), 7.23–7.25 (m, 2H), 7.45–7.48 (m, 2H), 7.56 (t, J = 8.0 Hz, 1H);
13C NMR (CDCl3, 100 MHz): δ 51.5, 61.8, 66.3, 110.2, 113.3 (d, J = 2.8 Hz), 114.7, 121.4 (d, J = 272.7 Hz), 127.8, 127.9, 128.8, 131.1, 132.3, 135.7, 139.4, 145.3 (q, J = 35.3 Hz), 159.9, 163.6, 168.0;
ESI-MS (m/z) 390 [M + Na]+. The data conforms to that described in the literature.)
Worthington, P. A.; Munns, G. R.; Jones, R. V. H.; Standen, M. C. H.; Ritchie, D. J.; Forrester, J.Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl)phenylacetate. WO patent 9701538,1997; CAN 126:171489
New Manufacturing Route to Picoxystrobin
† School
of Perfume and Aroma Technology, Shanghai
Institute of Technology, 100 Haiquan Road, Shanghai 201418, P. R. China
‡ Shanghai
Research Institute of Fragrance and Flavor Industry, 480 Nanning Road, Shanghai 200232, P. R. China
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.5b00371
Publication Date (Web): January 26, 2016
Copyright © 2016 American Chemical Society
Abstract
A
new and efficient manufacturing technology is disclosed in the present
work for the preparation of picoxystrobin in which all of the
intermediates can be used directly in the next step of the process
without purification.
http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00371
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Ancient
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