An efficient Passerini tetrazole reaction (PT-3CR)

Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC00910G, Communication

Ajay L. Chandgude, Alexander Domling
A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed.

An efficient Passerini tetrazole reaction (PT-3CR)

see
http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00910G?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

An efficient Passerini tetrazole reaction (PT-3CR)

Ajay L. Chandgude^a and   Alexander Dömling*^a  

*

Corresponding authors

^a

Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands 
E-mail: a.s.s.domling@rug.nl
Web: http://www.drugdesign.nl/

Green Chem., 2016, Advance Article

DOI: 10.1039/C6GC00910G

 A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed. It comprises the reaction of an aldehyde/ketone, an isocyanide and a TMS-azide in methanol:water (1:1) as the solvent system. The use of sonication not only accelerated the rate of the reaction but also provided good to excellent quantitative yields. This reaction is applicable to a broad scope of aldehydes/ketones and isocyanides.

  
Ajay L. Chandgude

• 
  University of Groningen

  Groningen Research Institute of Pharmacy (GRIP)

  Groningen, Netherlands

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Nyanza, Rwanda.

 

Nyanza

Town in Rwanda

Nyanza is a town located in Nyanza District in the Southern Province of Rwanda. The old Royal Palace of the Rwandan monarchy is located in the town of Nyanza. It is now the Rwesero Art Museum. Wikipedia

 

 

 

 

 

 

 

 

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