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Showing posts with label Sinjar. Show all posts
Showing posts with label Sinjar. Show all posts

Sunday 3 July 2016

Synthesis and pharmacological evaluation of novel 2H/6H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile derivatives

(a) PPh3, C2Cl6/TEA, toluene/reflux 2h; (b) dry toluene, CS2; (c) RCHO, ....



 Scheme 1.
(a) PPh3, C2Cl6/TEA, toluene/reflux 2 h; (b) dry toluene, CS2; (c) RCHO, ClCH2COOH, fused CH3COONa, reflux; (d) piperidine, THF, rt.


(Z)-2-Benzylidene-7-isocyano-3,6-dioxo-8-phenyl-3,6-dihydro-2H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile (4a)

White solid in a yield of 87%, mp 146–148 °C; IR (KBr, cm−1): 3032 (Ar-H), 1730 (Cdouble bond; length as m-dashO), 1590 (Cdouble bond; length as m-dashN), 1H NMR (300 MHz, DMSO-d6): δ 8.20 (s, 1H, CH), 7.60–7.55 (m, 2H, Ar-H), 7.45–7.33 (m, 6H, Ar-H), 7.19–7.17 (m, 2H, Ar-H), LC–MS (m/z, %): 422 (M+1)+. Anal. Calcd for C23H11N5O2S: C, 64.25; H, 2.55; N, 16.57. Found: C, 65.55; H, 2.63; N, 16.62.



3-Hydroxy-7-isocyano-6-oxo-8-phenyl-2-(phenyl(piperidin-1-yl)methyl)-6H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile (5a)

Colorless crystals in a yield of 67%, mp 130–132 °C; IR (KBr, cm−1): 3100 (O–H), 3030 (Ar-H), 2960 (C–H aliphatic), 1730 (Cdouble bond; length as m-dashO), 1590 (Cdouble bond; length as m-dashN), 1H NMR (300 MHz, DMSO-d6): 7.70–7.30 (m, 10H, Ar-H), 6.90 (s, 1H, CH), 3.7–3.22 (m, 4H, N(CH2)2), 1.7–1.4 (m, 6H, (CH2)3). LC–MS (m/z, %): 507 (M+1)+. Anal. Calcd for C28H22N6O2S: C, 66.93; H, 5.02; N, 16.95. Found: C, 66.39; H, 4.38; N, 16.59.


Volume 9, Issue 1, January 2016, Pages 136–142

Synthesis and pharmacological evaluation of novel 2H/6H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile derivatives

  • Department of Chemistry, S.V. University, Tirupati 517502, India
 http://www.sciencedirect.com/science/article/pii/S1878535211000451



SURESH MADDILA

NRF-DST Innovation Post-Doctoral Research Scientist at University of KwaZulu Natal, West Ville Campus, Durban
 

NRF-DST Innovation Post-doctoral Research Scientist

University of Kwazulu Natal, WestVille Campus, Durban
– Present (5 years 7 months)School of Chemistry & Physics., University of KwaZulu Natal, Durban
Currently, I am working as a NRF-DST Innovation Post-Doctoral Researcher at UKZN on temporary basis for a period of 1 month. I further extended my research by deriving the data from various syntheses of organic molecules, photocatalysis with ozone and synthesis of homogeneous & heterogeneous catalysts. The derived data has been compared and validated with the various spectroscopic techniques like 1H NMR, 13C NMR, MASS, IR spectroscopic data. In addition, I started my work towards middle homogeneous & heterogeneous photocatalysis and ozonation using different GC, XRD, SEM, TEM, BET, RAMAN, UV, UV-DRS, IR and spectrophotometers. The working group has been carried out under my investigation.


Teaching Assistant

Sri Venkateswara University, Tirupati, India.
(4 years 3 months)
Inorganic, Organic Chemistry & Physical Chemistry, Spectroscopy and Environmental Science

 

 MOM WILL TEACH YOU NMR


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 Sinjar, Nineveh Province, Iraq
 SINJAR IRAQ
Map of Sinjar Iraq
Sinjar
Town in Iraqi Kurdistan
Sindjar, also known as Shingal and formerly Sanjár, is a town in Sinjar District, Nineveh Province, Iraq near Mount Sinjar. Its population in 2013 was estimated at 88,023. Wikipedia



 

 

 

 

 
 
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