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Showing posts with label Tharparkar District. Show all posts
Showing posts with label Tharparkar District. Show all posts

Thursday 14 July 2016

(1S,6R)-9-Oxa-3-azabicyclo[4.2.1]nonane


STR1                    STR1   9-Oxa-3-azabicyclo[4.2.1]nonane.png

9-Oxa-3-azabicyclo[4.2.1]nonane

9-Oxa-3-azabicyclo[4.2.1]nonane;  CAS 69928-94-5;
Molecular Formula:C7H13NO
Molecular Weight:127.18422 g/mol
Figure
(1R,3r,5S)-2′-((S)-1-Phenylethyl)-8-oxaspiro[bicyclo[3.2.1]octane-3,3′-[1,2]oxaziridine] (13)
(13) as a light orange oil. 1H NMR (300 MHz, CDCl3) δ 7.48–7.40 (m, 2H), 7.39–7.27 (m, 3H), 4.44–4.35 (m, 1H), 4.33–4.24 (m, 1H), 3.48 (q, J = 6.3 Hz, 1H), 2.33 (ddd, J = 12.9, 4.5, 3.5 Hz, 2H), 1.89 (d, J = 14.8 Hz, 1H), 1.71–1.60 (m, 1H), 1.55 (t, J = 4.2 Hz, 3H), 1.54–1.47 (m, 1H), 1.42–1.29 (m, 2H), 0.32 (ddd, J = 11.1, 6.9, 3.4 Hz, 1H) ppm. 13C NMR (75 MHz, CDCl3) δ 141.0, 128.8, 128.1, 127.1, 82.0, 73.9, 73.3, 63.3, 43.0, 27.7, 27.6, 24.4 ppm.
(1S,6R)-3-((S)-1-Phenylethyl)-9-oxa-3-azabicyclo[4.2.1]nonan-4-one (14)
1H NMR (300 MHz, CDCl3) δ 7.29 (dddd, J = 15.5, 7.3, 5.0, 1.2 Hz, 5H), 6.18–6.04 (m, 1H), 4.38 (tt, J = 9.0, 7.7 Hz, 2H), 3.14 (d, J = 15.7 Hz, 1H), 2.92–2.75 (m, 3H), 2.11–1.82 (m, 4H), 1.50 (d, J= 7.1 Hz, 3H) ppm. 13C NMR (75 MHz, CDCl3) δ 173.59, 140.25, 128.53, 127.37, 127.21, 75.61, 72.25, 51.03, 50.50, 50.44, 47.88, 28.75, 26.44, 16.01 ppm. [α]21.8D = 160.2° (c = 1, 100 mg/10 mL of MeOH).
(1S,6R)-3-((S)-1-Phenylethyl)-9-oxa-3-azabicyclo[4.2.1]nonane (15)
15 as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 7.44–7.24 (m, 5H), 4.45 (t, J = 8.4 Hz, 1H), 4.38–4.28 (m, 1H), 3.85–3.74 (m, 1H), 2.77 (ddd, J = 19.5, 8.8, 4.1 Hz, 1H), 2.58 (dd, J = 10.6, 3.4 Hz, 2H), 2.43–2.28 (m, 1H), 2.23–2.06 (m, 1H), 2.02–1.84 (m, 4H), 1.44–1.29 (m, 4H) ppm. [α]19.2D = 25.683 (c = 0.989, 98.9 mg in 10 mL of MeOH).
(1S,6R)-9-Oxa-3-azabicyclo[4.2.1]nonane 11 as a white solid. 1H NMR (300 MHz, CDCl3) δ 9.88 (s, 1H), 9.34 (s, 1H), 4.71–4.31 (m, 2H), 3.56–2.88 (m, 4H), 2.49–1.70 (m, 6H) ppm.
ESI-MS found 128.0 (M + 1 +. [α]22.0D = −10.88 (c = 0.92, 92 mg in 10 mL of MeOH).
OLD SYNTHESIS


Figure
1H NMR predict
(1S,6R)-9-Oxa-3-azabicyclo[4.2.1]nonane

STR1
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EXPT  1H NMR (300 MHz, CDCl3) δ 9.88 (s, 1H), 9.34 (s, 1H), 4.71–4.31 (m, 2H), 3.56–2.88 (m, 4H), 2.49–1.70 (m, 6H) ppm.


13C NMR PREDICT
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REFERENCES
http://pubs.acs.org/doi/full/10.1021/acs.oprd.6b00213

//////////////////Chiral Bicyclic Lactam
C1CC2CCNCC1O2


 Pakistan,  Sindh

Map of Tharparkar District
Tharparkar District
Tharparkar District, is one of the twenty nine districts of Sindh province in Pakistan. It is headquartered at Mithi. It has the lowest Human Development Index of all the districts in Sindh. Wikipedia


3rd Highest peak of Karoonjhar about 1061 ft Altitude.. Latitude and Longitude on Globe is 24.20.54.42N 70.43.05.87E

Latitude and Longitude on Globe is 24.20.54.42N 70.43.05.87E

2nd Highest peak of Karoonjhar about 1067 ft Altitude.. Latitude and Longitude on Globe is 24.19.45.20N 70.43.19.69E

2nd Highest peak of Karoonjhar about 1067 ft Altitude.. Latitude and Longitude on Globe is 24.19.45.20N 70.43.19.69E


Highest peak of Karoonjhar about 1077 ft Altitude.. Latitude and Longitude on Globe is 24.20.12.38N 70.45.43.90E

Highest peak of Karoonjhar 


Kakbanglow Rd near Mirpur Khas Sindh

Kakbanglow Rd near Mirpur Khas Sindh


Main gate of Mir Mehboob Ali Talpur (MPA) Mir Landhi Sindh

Main gate of Mir Mehboob Ali Talpur (MPA) Mir Landhi Sindh


Main outer entrance of Mir Landhi village for residential area

 

Main outer entrance of Mir Landhi village for residential area


























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