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Showing posts with label sindh. Show all posts
Showing posts with label sindh. Show all posts

Thursday 14 July 2016

(1S,6R)-9-Oxa-3-azabicyclo[4.2.1]nonane


STR1                    STR1   9-Oxa-3-azabicyclo[4.2.1]nonane.png

9-Oxa-3-azabicyclo[4.2.1]nonane

9-Oxa-3-azabicyclo[4.2.1]nonane;  CAS 69928-94-5;
Molecular Formula:C7H13NO
Molecular Weight:127.18422 g/mol
Figure
(1R,3r,5S)-2′-((S)-1-Phenylethyl)-8-oxaspiro[bicyclo[3.2.1]octane-3,3′-[1,2]oxaziridine] (13)
(13) as a light orange oil. 1H NMR (300 MHz, CDCl3) δ 7.48–7.40 (m, 2H), 7.39–7.27 (m, 3H), 4.44–4.35 (m, 1H), 4.33–4.24 (m, 1H), 3.48 (q, J = 6.3 Hz, 1H), 2.33 (ddd, J = 12.9, 4.5, 3.5 Hz, 2H), 1.89 (d, J = 14.8 Hz, 1H), 1.71–1.60 (m, 1H), 1.55 (t, J = 4.2 Hz, 3H), 1.54–1.47 (m, 1H), 1.42–1.29 (m, 2H), 0.32 (ddd, J = 11.1, 6.9, 3.4 Hz, 1H) ppm. 13C NMR (75 MHz, CDCl3) δ 141.0, 128.8, 128.1, 127.1, 82.0, 73.9, 73.3, 63.3, 43.0, 27.7, 27.6, 24.4 ppm.
(1S,6R)-3-((S)-1-Phenylethyl)-9-oxa-3-azabicyclo[4.2.1]nonan-4-one (14)
1H NMR (300 MHz, CDCl3) δ 7.29 (dddd, J = 15.5, 7.3, 5.0, 1.2 Hz, 5H), 6.18–6.04 (m, 1H), 4.38 (tt, J = 9.0, 7.7 Hz, 2H), 3.14 (d, J = 15.7 Hz, 1H), 2.92–2.75 (m, 3H), 2.11–1.82 (m, 4H), 1.50 (d, J= 7.1 Hz, 3H) ppm. 13C NMR (75 MHz, CDCl3) δ 173.59, 140.25, 128.53, 127.37, 127.21, 75.61, 72.25, 51.03, 50.50, 50.44, 47.88, 28.75, 26.44, 16.01 ppm. [α]21.8D = 160.2° (c = 1, 100 mg/10 mL of MeOH).
(1S,6R)-3-((S)-1-Phenylethyl)-9-oxa-3-azabicyclo[4.2.1]nonane (15)
15 as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 7.44–7.24 (m, 5H), 4.45 (t, J = 8.4 Hz, 1H), 4.38–4.28 (m, 1H), 3.85–3.74 (m, 1H), 2.77 (ddd, J = 19.5, 8.8, 4.1 Hz, 1H), 2.58 (dd, J = 10.6, 3.4 Hz, 2H), 2.43–2.28 (m, 1H), 2.23–2.06 (m, 1H), 2.02–1.84 (m, 4H), 1.44–1.29 (m, 4H) ppm. [α]19.2D = 25.683 (c = 0.989, 98.9 mg in 10 mL of MeOH).
(1S,6R)-9-Oxa-3-azabicyclo[4.2.1]nonane 11 as a white solid. 1H NMR (300 MHz, CDCl3) δ 9.88 (s, 1H), 9.34 (s, 1H), 4.71–4.31 (m, 2H), 3.56–2.88 (m, 4H), 2.49–1.70 (m, 6H) ppm.
ESI-MS found 128.0 (M + 1 +. [α]22.0D = −10.88 (c = 0.92, 92 mg in 10 mL of MeOH).
OLD SYNTHESIS


Figure
1H NMR predict
(1S,6R)-9-Oxa-3-azabicyclo[4.2.1]nonane

STR1
STR1
EXPT  1H NMR (300 MHz, CDCl3) δ 9.88 (s, 1H), 9.34 (s, 1H), 4.71–4.31 (m, 2H), 3.56–2.88 (m, 4H), 2.49–1.70 (m, 6H) ppm.


13C NMR PREDICT
STR1

REFERENCES
http://pubs.acs.org/doi/full/10.1021/acs.oprd.6b00213

//////////////////Chiral Bicyclic Lactam
C1CC2CCNCC1O2


 Pakistan,  Sindh

Map of Tharparkar District
Tharparkar District
Tharparkar District, is one of the twenty nine districts of Sindh province in Pakistan. It is headquartered at Mithi. It has the lowest Human Development Index of all the districts in Sindh. Wikipedia


3rd Highest peak of Karoonjhar about 1061 ft Altitude.. Latitude and Longitude on Globe is 24.20.54.42N 70.43.05.87E

Latitude and Longitude on Globe is 24.20.54.42N 70.43.05.87E

2nd Highest peak of Karoonjhar about 1067 ft Altitude.. Latitude and Longitude on Globe is 24.19.45.20N 70.43.19.69E

2nd Highest peak of Karoonjhar about 1067 ft Altitude.. Latitude and Longitude on Globe is 24.19.45.20N 70.43.19.69E


Highest peak of Karoonjhar about 1077 ft Altitude.. Latitude and Longitude on Globe is 24.20.12.38N 70.45.43.90E

Highest peak of Karoonjhar 


Kakbanglow Rd near Mirpur Khas Sindh

Kakbanglow Rd near Mirpur Khas Sindh


Main gate of Mir Mehboob Ali Talpur (MPA) Mir Landhi Sindh

Main gate of Mir Mehboob Ali Talpur (MPA) Mir Landhi Sindh


Main outer entrance of Mir Landhi village for residential area

 

Main outer entrance of Mir Landhi village for residential area


























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Thursday 14 August 2014

TIMOLOL

(S)-1-[(1,1-dimethylethyl)amino]-3-{[4-morpholinyl)-1,2,5-thiadiazol-3yl]oxy}-2-propanol.

Timolol maleate

The structural formula






UV - spectrum

Conditions : Concentration - 3 mg / 100 ml
Solvent designation schedule
Methanol 
Water 
0.1 M HCl 
0.1M NaOH 
The absorption maximum299 nm-295 nm296 nm
210-197206
ε9070-85408920

IR - spectrum

Wavelength (μm)
Wavenumber (cm -1 )



Mass Spectrum

Spectrum (for the base)
The 10 largest peaks:
Peak30415657707486114128130
Meaning376851071687214499910283214

SEE FULL CHAPTER AT

http://books.google.co.in/books?id=tQiZCwMb2jAC&pg=PA641&source=gbs_toc_r&cad=4#v=onepage&q&f=false


OR CLICK








  1. Profiles of Drug Substances, Excipients and Related ...

    books.google.com › Science › Chemistry › Organic

    Front Cover. Klaus Florey. Academic Press, Sep 4, 1987 - Science - 770 pages ... Chapter 15 Timolol Maleate. 641. 


http://www.google.com/patents/US5231095
The crystal structure for S-timolol hemihydrate (single crystals from water-methylene chloride) was measured with a Enraf-Nonius CAD-4 diffractometer using graphite-monochromatized MoK.sub.α (0.71073 Å) and ω-2θ method at 21° C. The cell parameters and orientation matrix were determined from 18 reflections (6<θ<10°). The measuring rate (° min-1) was 0.87-16.5, width (θ) 0.5+0.344tan θ and area (θ) 2-25. The following crystal data were obtained: spaced group monoclinic, C2 (No. 5); a=23.435(3) Å, b=6.384(8) Å, c=11.591(1) Å, α=90.00, β=103.081(1), γ=90.00, V=1687(3) Å, Z=2, d=1.281 gcm-3.
The results obtained with a NMR spectrometer support the above obtained X-ray diffraction results (Instrument Bruker AC 250/Aspect 3000). 1 H-NMR (solvent CDCl3) δ (ppm): 1.09 (s, 9H), 2.0 (b, appr. 2.5H), 2.57 (d+d, 1H; 12.0 and 8.0 Hz), 2.80 (d+d, 1H; 12.0 and 4.0 Hz), 3.52 (m, 4H), 3.79 (m, 4H), 3.91 (m, 1H), 4.36 (d+d, 1H; 11.1 and 5.8 Hz), 4.47 (d+d, 1H; 11.1 and 4.1 Hz).
13 C NMR (solvent CDCl3) 6 (ppm): 28.91 (g), 50.24 (s), 44.33 (t), 66.10 (d), 72.76 (t), 153.66 (s), 149.78 (s), 47.78 (t), 66.33 (t).
S-timol hemihydrate has also been analyzed thermogravimetrically (Perkin Elmer, TGS-2 thermogravimetric analyzer and attached differential scanning DSC 4 calorimeter). The TG graph indicates splitting off of the hydrate water at about 50° C., the DSC gives a melting point of 53.3° C.





Markku Per alampi, “S-timolol hemihydrate composition and method of preparation therefor.” U.S. Patent US5574035, issued October, 1986.
US5574035 

Patents

US 6174524, US 5231095

Links

  • UV and IR Spectra. H.-W. Dibbern, RM Muller, E. Wirbitzki, 2002 ECV
  • NIST / EPA / NIH Mass Spectral Library 2008
  • Handbook of Organic Compounds. NIR, IR, Raman, and UV-Vis Spectra Featuring Polymers and Surfactants, Jr., Jerry Workman.Academic Press, 2000.
  • Handbook of ultraviolet and visible absorption spectra of organic compounds, K. Hirayama. Plenum Press Data Division, 1967.

Timolol
Timolol Structural Formulae.png
Timolol ball-and-stick.png
Systematic (IUPAC) name
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Clinical data
Trade namesTimoptic
AHFS/Drugs.commonograph
MedlinePlusa602022
Pregnancy cat.(AU) C (US)
Legal status Prescription only
Routesoral, Ophthalmic
Pharmacokinetic data
Bioavailability60%
MetabolismHepatic: 80%
Half-life2.5-5 hours
ExcretionRenal
Identifiers
CAS number26839-75-8 Yes
ATC codeC07AA06 S01ED01
PubChemCID 33624
IUPHAR ligand565
DrugBankDB00373
ChemSpider31013 Yes
UNII5JKY92S7BR Yes
KEGGD08600 Yes
ChEBICHEBI:9599 Yes
ChEMBLCHEMBL499 Yes
Chemical data
FormulaC13H24N4O3S 
Mol. mass316.421 g/mol


SYNTHESIS
















AZERBAIJAN


http://www.baldhiker.com/wp-content/uploads/PC180077azerbaijan-food.jpg







Caucasus Mountains in northern Azerbaijan.




Image result for azerbaijan flag map







Justice for Khojaly













Bibi Heybat Mosque






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sindh, pakistan,INSTITUTE OF CHEMISTRY UNIVERSITY OF SINDH JAMSHORO











INSTITUTE OF CHEMISTRY UNIVERSITY OF SINDH JAMSHORO















jAMSHORO



















Food Festival organized by Institute of English Language and Literature UoS , Jamshoro.