Ulipristal acetate NMR

Ulipristal acetate

(8S,11S,13S,14R,17R)-17-Acetoxy-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

EMA:Link, US FDA:link

REVIEW.http://www.fsrh.org/pdfs/ellaOneNewProductReview1009.pdf

126784-99-4 CAS

http://www.google.com.br/patents/US5929262

CA2216737A1, EP0817793A2, WO1996030390A2, WO1996030390A3

1. The United States Of America As Represented By The Department Of Health And Human Services

m.p. 183-185

IR

1735 and 1714(--C═O), 1664 and 1661 (conjugated --C═O), 1563, 1518, 1441, 1351, 1305, 1252, 1203, 1171;

NMR (CDCl.sub.3)

δ0.38 (s, 18-CH.sub.3),

2.10 (s, 17-OAc),

2.14 (s, 21-CH.sub.3),

2.92 (s, --N(CH.sub.3).sub.2,

4.44 (d, C-11 H),

5.83 (br. s, C-4 H),

6.71 and 7.07 (d, aromatic H);

MS(EI) m/z (relative intensity) 475(M.sup.+, 41), 134(18), 121 (100).

Analysis calculated for C.sub.30 H.sub.37 NO.sub.4 : C, 75.76; H, 7.84; N, 2.94. Found. C, 75.80; H 7.96; N, 3.09.

http://newdrugapprovals.org/2014/04/07/ulipristal-acetate-for-emergency-contraception/