2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanol
2,2,2-trifluoro-1-(4-methoxyphenyl)-ethanol
2,2,2-trifluor-1-(4-methoxyphenyl)ethanol 2,2,2-trifluoro-1-(4-méthoxyphényl)éthanol 2,2,2-トリフルオロ-1-(4-メトキシフェニル)エタノール | |||||
Physical Properties
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H1 NMR Spectrum:
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Data
1H NMR (CDCl3, 400 MHz) d ppm 3.24 - 3.37 (m, 1 H)
3.80 (s, 3 H) O-CH3
4.91 (q, J=6.85 Hz, 1 H) C-H
6.92 (d, J=8.80 Hz, 2 H) arom-H ortho to oxygen
7.37 (d, J=8.80 Hz, 2 H) arom-H
3.80 (s, 3 H) O-CH3
4.91 (q, J=6.85 Hz, 1 H) C-H
6.92 (d, J=8.80 Hz, 2 H) arom-H ortho to oxygen
7.37 (d, J=8.80 Hz, 2 H) arom-H
13C NMR (CDCl3, 101 MHz) d ppm
55.51 (CH3) O-CH3
72.60 (q, JC-C-F = 31.50 Hz, CH) CH-(OH)-CF3
114.28 (CH) AROM-C
120.44 – 128.84 (q, JC-F = 281.70 Hz, CF3)
126.54 (d, JC-C-C-F = 1.47 Hz, CH) CARBON ATOM ON AROM RING ATTACHED TO -CH-(OH)-CF3
129.07 (C) AROM-C META TO OXYGEN ATOM
160.60 (C) AROM C-O-CH3
55.51 (CH3) O-CH3
72.60 (q, JC-C-F = 31.50 Hz, CH) CH-(OH)-CF3
114.28 (CH) AROM-C
120.44 – 128.84 (q, JC-F = 281.70 Hz, CF3)
126.54 (d, JC-C-C-F = 1.47 Hz, CH) CARBON ATOM ON AROM RING ATTACHED TO -CH-(OH)-CF3
129.07 (C) AROM-C META TO OXYGEN ATOM
160.60 (C) AROM C-O-CH3
19F NMR (CDCl3, 377 MHz) d ppm -78.61 (d, J = 6.81 Hz)
GC-MS (EI) 206 ([M]+, 37%), 137 (100%), 109 (27%), 94 (28%), 77 (25%), 69 (4%).
Kelly, C. B.; Colthart, A. M.; Constant, B.D.; Corning, S.R.; Dubois, L. N. E.; Genovese, J. T.; Radziewicz, J. L.; Sletten, E. M.; Whitaker, K. R.; Tilley, J. J. Org. Lett.2011, 13, 1646.
Krishnamurti, R.; Bellew, D. R.; Prakash, G. K. S. J. Org. Chem. 1991, 56, 984.
DOI: 10.1021/jo00001a002
DOI: 10.1021/jo00001a002