Structure, mechanism and exchange processes in molecules
Using NMR spectroscopy as our primary tool, backed up wuth computational methods, structures of compounds and the mechanism of fluxional processes is explored. A couple of examples one each from inorganic and organic chemistry are shown below.- Hydrides and dihydrogen complexes
Hydride and dihydrogen complexes also often show interesting mechanisms of fluxionality, i.e.,
the hydrogen atoms interchange their positions within the complexes.
NMR is ideally suited to revealing how these molecular reorientations
take place.
Studying exchange in a polyhydride complex
- Photochromic organic compounds
Elucidating an acid catalysed isomerization process in a photomerocyanine compound at -80 °C.
We
are currently investigating several other photochemically generated
organic reactive intermediates with NMR spectroscopy at low
temperatures.References:
Yee, L. H.; Hanley, T.; Evans, R. A.; Davis, T. P.; Ball, G. E. "Photochromic Spirooxazines Functionalized with Oligomers: Investigation of Core-Oligomer Interactions and Photomerocyanine Isomer Interconversion Using NMR Spectroscopy and DFT" J. Org. Chem. 2010, 75, 2851-2860.
Evans, R.A; Hanley, T.L.; Skidmore, M.A.; Davis, T.P.; Such, G.K.; Yee, L.H; Ball, G.E.; Lewis, D.A. "Lubrication and Control of Nano-Mechanical Processes in Polymers." Nature Materials, 2005, 4, 193.
amcrasto@gmail.com
http://newdrugapprovals.org/
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
amcrasto@gmail.com
http://newdrugapprovals.org/
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO