Novel 1,3-Dipolar Cycloadditions of Cyclobutene Diester Epoxides to Polycyclic Aromatic Hydrocarbons

http://www.mdpi.org/ecsoc/ecsoc-7/papers/a009/a009.htm

Novel 1,3-Dipolar Cycloadditions of Cyclobutene Diester Epoxides to Polycyclic Aromatic Hydrocarbons [1]

Davor Margetiæ,*^A Ronald N. Warrener^B and Douglas N. Butler^B

A Laboratory for Physical Organic Chemistry,

Department of Organic Chemistry and Biochemistry,
Ruðer Boškoviæ Institute, Bijenièka c. 54, 10000 Zagreb, Croatia
(*) Corresponding author. Email: margetid@emma.irb.hr
^B Centre for Molecular Architecture,
Central Queensland University, Rockhampton, Queensland, 4702, Australia

http://www.mdpi.org/ecsoc/ecsoc-7/papers/a009/a009.htm




























Zagreb is the capital of Croatia and one of the must-see places in Croatia. It has a population of roughly 800,000 people and it is a transportation hub ...





http://croatia-wave.com/locations/info/zagreb




Old town and cathedral from Gradec in Zagreb, Croatia





Trg Bana Jelacica Square Zagreb, Croatia

http://www.travelpulse.com/news/hotels-and-resorts/doubletree-by-hilton-zagreb-to-open-next-year-in-croatia.html

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Join me on Linkedin

Join me on Facebook FACEBOOK

Join me on twitter     

Join me on google plus Googleplus

 amcrasto@gmail.com

Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves

 

compound (1) is 7-[(β-D-glucopyranosyl)oxy]-6- hydroxy-2-methoxy-6,7-dihydro-1,3-thiazepine and trivially named as `Rubiothiazepine` (Structure I).
 

Citation: Mohammed MMD, Ibrahim NA, Chen M, Zhai L (2014) Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves. Nat Prod Chem Res 2:128 doi: 10.4172/2329-6836.1000128

http://esciencecentral.org/journals/rubiothiazepine-a-novel-unusual-cytotoxic-alkaloid-from-ixora-undulata-roxb-leaves-2329-6836.1000128.php?aid=24194

Magdy M. D. Mohammed1,2*, Nabaweya A Ibrahim2, Ming Chen3 and Lin Zhai3
1Danish Institute of Agricultural Sciences, Department of Food Science, Research Center Aarslev, Kirstinebjergvej 10, DK-5792 Aarslev, Denmark
2Pharmacognosy Department, National Research Center, Dokki-12311, Cairo, Egypt
3Department of Clinical Microbiology, University Hospital of Copenhagen (Rigshospitalet), Tagensvej 20, DK-2200 Copenhagen N, Denmark
Corresponding Author :	Magdy Mostafa Desoky Mohammed Danish Institute of Agricultural Sciences Department of Food Science, Research Center Aarslev Kirstinebjergvej 10, DK-5792 Aarslev, Denmark Tel: 00201022610332 E-mail: melhenawy111@gmail.com   Magdy M. D. Mohammed Assistant Professor of Chemistry of Medicinal and Aromatic Plants, Pharmacognosy Department
.............
Magdy M. D. Mohammed Assistant Professor of Chemistry of Medicinal and Aromatic Plants, Pharmacognosy Department Dikutip oleh Tahun Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt NA Ibrahim, HR El-Seedi, MMD Mohammed Natural product research 21 (10), 857-866 16 2007 Anti-HIV-1 and cytotoxicity of the alkaloids of Erythrina abyssinica Lam. growing in Sudan MMD Mohammed, NA Ibrahim, NE Awad, AA Matloub, AG Mohamed-Ali, ... Natural product research 26 (17), 1565-1575 6 2012 Two new phorbol-type diterpene esters from Synadenium grantii Hook f. leaves EM Hassan, MMD Mohammed, SM Mohamed Records of Natural Products 6 (3), 255-262 6 2012 The cytotoxic activity of Linum grandiflorum leaves MMD Mohammed, M Chen, L Zhai, NA Ibrahim European Journal of Chemistry 1 (2), 110-114 6 2010 New acylated flavone and cyanogenic glycosides from Linum grandiflorum MMD Mohammed, LP Christensen, NA Ibrahim, NE Awad, IF Zeid, ... Natural product research 23 (5), 489-497 5 2009 Constituents and biological activity of the chloroform extract and essential oil of Cupressus sempervirens NA Ibrahim, HR El-Seedi, MMD Mohammed Chemistry of natural compounds 45 (3), 309-313 4 2009 Anti-HIV-1 activities of the extracts from the medicinal plant Linum grandiflorum Desf MMD Mohammed, LP Christensen, NA Ibrahim, NE Awad, IF Zeid, ... Med. Aroma. Plant Sci. Biotechnol 3, 37-41 3 2009 Cytotoxic flavonoids from Diplotaxis harra (Forssk.) Boiss. growing in Sinai MMD Mohammed, ER El-Sharkawy, AA Matloub Journal of Medicinal Plants Research 7 (1), 19-23 1 2013 Anti-HIV-1 and cytotoxicity of the alkaloids of Erythrina abyssinica Lam. growing in Sudan MM Mohammed, NA Ibrahim, NE Awad, AA Matloub, AG Mohamed-Ali, ... Erratun in Nat Prod Res 27, 295 1 2013 Cytotoxic flavonoids from Diplotaxis harra (Forssk.) Boiss. growing in Sinai M Mohammed, ER El-Sharkawy, AA Matloub JOURNAL OF MEDICINAL PLANTS RESEARCH 5 (20), 5099-5103 1 2011 Anti-influenza A virus activity of a new dihydrochalcone diglycoside isolated from the Egyptian seagrass Thalassodendron ciliatum (Forsk.) den Hartog MMD Mohammed, AHA Hamdy, NM El-Fiky, WSA Mettwally, AA El-Beih, ... Natural product research 28 (6), 377-382 2014 Isolation and anti-HIV-1 activity of a new sesquiterpene lactone from Calocephalus brownii F. Muell. MMD Mohammed, LP Christensen, PL Colla Natural product research 28 (4), 221-229 2014 Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata MMD Mohammed, NA Ibrahim, M Chen, L Zhai Roxb. Leaves. Nat Prod Chem Res 2 (128), 2 2014 Antiviral and cytotoxic activities of anthraquinones isolated from Cassia roxburghii Linn. leaves M Mohammed, SS El-Souda, SM El-Hallouty, N Kobayashi Herba Polonica 59 (4), 33-44 2013 4th World Congress on Bioavailability and Bioequivalence: Pharmaceutical R&D Summit MMD Mohammed 2013 Chemical composition, antimicrobial activity of the essential oil of the flowers of Paulownia tomentosa (Thunb.) Steud. growing in Egypt. ES Ibrahim, N.A., El-Hawary, S.S., Magdy M. D. Mohammed, Faraid, M.A ... Journal of Applied Sciences Research 9 (4), 3228-3232 2013 D-mannitol in ameliorating some metabolic disorders in Schistosomal mansoni infected mice. MMDM Nagy S. El-Rigal, Sanaa A. Ali, Mohga S. Abd-Allah, El-Sayed M. El ... Egyptian Pharmaceutical Journal 10 (2), 137–166 2011 POTENTIAL ANTICANCER AGENTS FROM LINUM GRANDIFLORUM LEAVES M Mohammed, M Chen, L Zhai, NA Ibrahim ANTICANCER RESEARCH 28 (5 C), 3411-3411 DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE Join me on Linkedin Join me on Facebook FACEBOOK Join me on twitter      Join me on google plus Googleplus  amcrasto@gmail.com

Boric Ester-Type Molten Salt via Dehydrocoupling Reaction

Figure 1. ¹H-NMR of 5 (solvent: CDCl₃; 10%; r.t.; TMS; 400 MHz).


http://www.mdpi.com/1422-0067/15/11/21080

http://www.mdpi.com/1422-0067/15/11/21080/htm

Int. J. Mol. Sci. 2014, 15(11), 21080-21089; doi:10.3390/ijms151121080

Article

Boric Ester-Type Molten Salt via Dehydrocoupling Reaction

Noriyoshi Matsumi ^1,*, Yoshiyuki Toyota ¹, Prerna Joshi ¹, Puhup Puneet ¹, Raman Vedarajan ¹ and Toshihiro Takekawa ²

¹School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan; E-Mails: brothertobrother@gmail.com (Y.T.); joshi.prerna2011@gmail.com (P.J.); rupakagain2008@gmail.com (P.P.); raman@jaist.ac.jp (R.V.)

²Advanced Materials Laboratory, Nissan Motor Co., Ltd., 1 Natsushima-cho, Yokosuka-shi, Kanagawa 237-8523, Japan; E-Mail: t-takekawa@mail.nissan.co.jp

*Author to whom correspondence should be addressed; E-Mail: matsumi@jaist.ac.jp; Tel.: + 81-761-51-1600; Fax: +81-761-51-1665.


 JOSHI PRERNA




Noriyoshi Matsumi

Figure 2. ¹³C-NMR of 5 (solvent: DMSO; r.t.; 100 MHz)



Figure 3. ¹¹B-NMR of 5 (solvent: CDCl₃; r.t.; external standard: B(OCH₃); 128 MHz).



Figure 4. ¹⁹F-NMR of 5 (solvent: CDCl₃; r.t.; external standard: C₆H₅CF₃; 376 MHz).


data
1H-NMR (CDCl3, δ, ppm) 1.26–2.50 (20H, 9-BBN), 3.98 (3H, CH3), 4.33 (2H, –NCH2CH2O), 5.62 (2H, –NCH2CH2OB–), 7.21, 7.35 (2H, –NCHCHN–), 8.87 (1H, –NCHN–). 

13C-NMR (DMSO-d6, δ, ppm) 23.3–33.2 (9-BBN), 36.1, 52.1, 59.8, 119.4 (q, CF3), 123.1–123.8 (N–C=C–N), 137.3 (N–C=N). 

11B-NMR (CDCl3, δδ, ppm) 33.3.






kanagawa japan















FOOD.















DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Join me on Linkedin

Join me on Facebook FACEBOOK

Join me on twitter     

Join me on google plus Googleplus

 amcrasto@gmail.com

13C NMR of dimethyl 3,4,5,6-tetraphenylphthalate

he upfield peak at 52.28 is in the expected position for C1, the ester methyl carbon. Down at the other end of the spectrum, the peak at 168.71 is in the expected position for an ester carbonyl carbon (C2).

In the region for aromatic carbons we see 5 low intensity peaks between 143 and 132. These belong to the (unprotonated) quaternary carbons 3, 4, 5, 6, 10. Using diethyl phthalate as a model compound, I would guess that the peak at 132.19 is from C3. The two peaks at 138.73 and 138.60 have the same height and are closely spaced suggesting very similar environments, I might guess them to be C6 and C10, just not sure which is which. Noting that the peak for the carbon corresponding to our C5 is downfield of the peak corresponding to our C4 in the model compound, I would expect the same trend to hold here, just with each of the peaks shifted downfield due to attachment of a phenyl group. So I would assign the peak at 143.27 to C5 and the peak at 139.29 to C4.

This leaves the protonated aromatic carbons for us to consider. The 2 peaks at 125.97 and 126.83 are half the intensity of the other protonated aromatic signals, therefor assign them to C9 and C13 as there are only half as many of these carbons as compared to the other protonated aromatic carbons. It's not clear which peak belongs to C9 and which to C13. This leaves us with the 4 signals due to C7, C8, C11 and C12. , I would expect C7 and C11 to be downfield from C8 and C12. Therefor, I would assign C7 and C11 to the peaks at 129.71 and 130.88, not knowing which is which. C8 and C12 then belong to the signals at 126.88 and 127.41, not knowing which belongs to which.

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Join me on Linkedin

Join me on Facebook FACEBOOK

Join me on twitter     

Join me on google plus Googleplus

 amcrasto@gmail.com