2-(1-Chloropropylethyl)pyridine

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Pokhara ,
Nepal

Pokhara looking south, with the white World Peace Pagoda on a hill to the right. 


Relaxing beside Lake Phewa.

Keeping it real part II. The booming ugly side of Pokhara. Photo by Sundar1.

Devi's Falls, where the river disappears into a sinkhole, 2kms southwest of the airport. The water depends on the season, so if it's the middle/end of the dry season, don't bother!

Pokhara Trekking

Pokhara looking north towards the Himalayas. Original Photo by Jean Marie Hullot .




The start of a pleasure trek for some, the end of a hard day foraging for others.


A sadhu at a little shrine on a day-hike trail to Sarangkot.


A guest house/tea house above Pokhara near Sarangkot.

 
 

 
 


 

 


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Picoxystrobin

 Picoxystrobin

1 as a white solid with 99% purity by HPLC (retention time: 9.1 min). mp 74–75 °C (lit. mp 73–74). 

 Worthington, P. A.; Munns, G. R.; Jones, R. V. H.; Standen, M. C. H.; Ritchie, D. J.; Forrester, J.Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl)phenylacetate. WO patent 9701538,1997; CAN 126:171489

1H NMR (CDCl3, 400 MHz): δ 3.57 (s, 3H), 3.68 (s, 3H), 5.25 (s, 2H), 6.78 (d, J = 8.4 Hz, 1H), 7.08–7.14 (m, 2H), 7.23–7.25 (m, 2H), 7.45–7.48 (m, 2H), 7.56 (t, J = 8.0 Hz, 1H); 

13C NMR (CDCl3, 100 MHz): δ 51.5, 61.8, 66.3, 110.2, 113.3 (d, J = 2.8 Hz), 114.7, 121.4 (d, J = 272.7 Hz), 127.8, 127.9, 128.8, 131.1, 132.3, 135.7, 139.4, 145.3 (q, J = 35.3 Hz), 159.9, 163.6, 168.0; 

ESI-MS (m/z) 390 [M + Na]+. The data conforms to that described in the literature.) 

Worthington, P. A.; Munns, G. R.; Jones, R. V. H.; Standen, M. C. H.; Ritchie, D. J.; Forrester, J.Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl)phenylacetate. WO patent 9701538,1997; CAN 126:171489

New Manufacturing Route to Picoxystrobin

Yu Chen^†‡, Huan Lu^‡, Hui Dai^‡, Wansheng Yu^‡, and Xianhua Pan^*†‡

^† School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, P. R. China

^‡ Shanghai Research Institute of Fragrance and Flavor Industry, 480 Nanning Road, Shanghai 200232, P. R. China

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.5b00371

Publication Date (Web): January 26, 2016

Copyright © 2016 American Chemical Society

*E-mail: panxh@sit.edu.cn. Tel: +86(21)54961786. Fax: +86(21) 54961786.

Abstract

A new and efficient manufacturing technology is disclosed in the present work for the preparation of picoxystrobin in which all of the intermediates can be used directly in the next step of the process without purification.

http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00371
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 erotic temples in nepal

 
 
 

 
 Ancient erotic woodcarving on Jagganath temple struts in central Kathmandu, possibly designed to stimulate a flagging birthrate. Yes, it does pay to look up occasionally!

http://www.123rf.com/photo_26597310_erotic-carving-explicit-kama-sutra-position-on-a-nepali-temple-in-patan-kathmandu-nepal.html

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