Methyl 5-(2,2-Dimethoxyethylcarbamoyl)-3-(benzyloxy)-1,4-dihydro-1-(2,2-dimethoxyethyl)-4-oxopyridine-2-carboxylate

Methyl 5-(2,2-Dimethoxyethylcarbamoyl)-3-(benzyloxy)-1,4-dihydro-1-(2,2-dimethoxyethyl)-4-oxopyridine-2-carboxylate (imp-2)

1H NMR (400 MHz, CDCl3) δ 10.1 (t, J = 5.2 Hz, 1H), 8.4 (s, 1H), 7.3–7.4 (m, 5H), 5.2 (s, 2H), 4.5(t, J = 5.2 Hz, 1H), 4.4 (t, J = 4.4 Hz, 1H), 4.0 (d, J = 4.4hz, 2H), 3.7 (s, 3H), 3.6 (t, J = 6.0 Hz, 2H), 3.4 (s, 6H), 3.3 (s, 6H) ; 

13C NMR (400 MHz, CDCl3) δ 173.2, 164.2, 162.1, 148.2, 144.4, 136.7, 134.8, 128.5, 128.3, 128.1, 119.3, 102.7, 102.4, 74.3, 56.8, 55.6, 53.9, 53.1, 40.8;

 IR (KBr, cm–1): 3201, 3045, 2949, 2835, 1734, 1662, 1610, 1548;

 ESI-MS m/z 479.26.

http://pubs.acs.org/doi/suppl/10.1021/acs.oprd.6b00156/suppl_file/op6b00156_si_001.pdf

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SIDON, LEBANON

Sidon

City in Lebanon

Sidon or Saïda is the third-largest city in Lebanon. It is located in the South Governorate of Lebanon, on the Mediterranean coast, about 40 kilometres north of Tyre and 40 km south of the capital, Beirut. Wikipedia

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NUCLEIC ACID ANALYSIS WITH UV-VIS AND NMR - SPECTROSCOPY

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NUCLEIC ACID ANALYSIS WITH UV-VIS AND NMR -

SPECTROSCOPY

• Spectroscopy,
• Vacuum,
• November,
• Column,
• Analysis,
• Nucleic,
• Columns,
• Acids,
• Ctmab,
• Inspection, 
Nucleic Acid Analysis,,  UV-vis and NMR - Spectroscopy

PROTEIN NMR TECHNIQUES PROTEIN NMR TECHNIQUES

PROTEIN NMR TECHNIQUES PROTEIN NMR TECHNIQUES ///////////// Protein, Proteins, Relaxation, Experiments, Dipolar, Methods, Spectra, Peak, Peaks, Analysis, Techniques, Protein NMR Techniques

MULTIDIMENSIONAL NMR

Basic 1H- and 13C-NMR Spectroscopy

Basic 1H- and 13C-NMR Spectroscopy by Elsevier Books Reference on Scribd

/////////////////////////Basic 1H- and 13C-NMR Spectroscopy

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful and theoretically complex analytical tool.Basic 1H- and 13C-NMR Spectroscopyprovides an introduction to the principles and applications of NMR spectroscopy. Whilst looking at the problems students encounter when using NMR spectroscopy, the author avoids the complicated mathematics that are applied within the field. Providing a rational description of the NMR phenomenon, this book is easy to read and is suitable for the undergraduate and graduate student in chemistry.

* Describes the fundamental principles of the pulse NMR experiment and 2D NMR spectra 
* Easy to read and written with the undergraduate and graduate chemistry student in mind
* Provides a rational description of NMR spectroscopy without complicated mathematics

(-)-7,8,3',4'-trihydroxy-8-(3'',7''-dimethyl-octa-2'',6''dienoyl)-flavanone

.

 (-)-7,8,3',4'-trihydroxy-8-(3'',7''-dimethyl-octa-2'',6''dienoyl)-flavanone


Compound 1 was isolated as a yellow solid with mp 96.3-97.1 ºC and optical rotation -108º (CHCl3; c 0.1). Its molecular formula of C22H24O11 was established by the quasi-molecular ion at m/z 409.20157 [M + H]+ in the HRESIMS spectrum. The absorption bands at 3366 cm-1 and 1748 in the IR spectrum, were consistent with hydroxyl and carbonyl groups, respectively. The analysis of 1H NMR spectrum in addition to the COSY experiment data revealed the presence of two sets of ABX coupling system protons, through the correlations of the aromatic hydrogens at δ 6.93 (dd, J 1.6, 8.2 Hz, H-2´), 6.81 (dd, J 1.6,8.2 Hz, H-6´) and 6.78 (d, J 8.2 Hz, H-5´), and of the hydrogens of a typical flavanone skeleton at δ 5.26 (dd, J 2.8, 12.9 Hz, H-2), 2.96 (dd, J 12.9, 16.9 Hz, H-3) and 2.68 (dd, J 2.8, 16.9, H-3´).17 The presence of a geranyl group was suggested from the characteristic signals of the three methyl groups at d 1.59 (s, H-10´´), 1.57 (s, H-8´´) and 1.52 (s, H-9´´), two olefinic hydrogens at δ 5.02 (t, J 6.0 Hz, H-6´´) and 5.17 (t, J 7.8 Hz, H-2´´), and three methylenes at δ 2.01 (d, J 7.8 Hz, H-4´´), 2.09 (m, H-5´´) and 3.44 (d, J 7.0 Hz, H-1´´). In the aromatic region of the spectrum, the two remaining aromatic protons occurred as a set of orto coupled doublets at δ 6.50 (d, J 8.7 Hz, H-6) and 7.57 (d, J 8.7 Hz, H-5).

(-)-7,8,3',4'-Trihydroxy-8-(3'',7''-dimethyl-octa-2'',6''dienoyl)-flavanone (1)

Yellow solid. mp 96.3-97.1 ºC. [α]_D²⁰ -108º (CHCl₃; c 0.1). IR (film) v _max /cm^-1: 3366, 2925, 2852, 1748, 1493, 1380, 1347, 1131, 1092, 1073, 1002, 944, 823, 702. HRESIMS [M + H] 409.20157 (calculated for C₂₅H₂₉O₅409.2016). EIMS m/z 408 ([M] 10%), 393, 365, 339, 285, 272, 229, 203, 161, 149, 136, 123, 69, 41.

Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053
On-line version ISSN 1678-4790

J. Braz. Chem. Soc. vol.20 no.5 São Paulo  2009

http://dx.doi.org/10.1590/S0103-50532009000500019 

ARTICLE

Pterocarpans and a novel flavanone fromharpalyce brasiliana roots

Renata M. de Araújo; Mary Anne S. Lima; Edilberto R. Silveira^*

Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12200, 60451-970 Fortaleza-CE, Brazil

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000500019&lng=en&nrm=iso

* e-mail: edil@ufc.br
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Grünersee, Grüner See, 

Austria

Grüner See

Lake in Austria

Grüner See is a lake in Styria, Austria in a village named Tragöß. The lake is surrounded by the Hochschwab Mountains and forests. The name "Green Lake" originated because of its emerald-green water. Wikipedia

Parent range: Alps

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TESTOSTERONE

Development of a Chemoenzymatic Process for Dehydroepiandrosterone Acetate Synthesis

Anna Fryszkowska†, Justine Peterson†, Nichola L. Davies†, Colin Dewar†, George Evans†, Matthew Bycroft†, Neil Triggs†, Toni Fleming†, Srikanth Sarat Chandra Gorantla‡, Garrett Hoge†, Michael Quirmbach§, Upadhya Timmanna‡, Srinivas Reddy Poreddy‡, D. Naresh Kumar Reddy‡, Vilas Dahanukar‡, and Karen E. Holt-Tiffin*†

† Chirotech Technology Centre, Dr. Reddy’s Laboratories EU Ltd., 410 Cambridge Science Park, Cambridge CB4 0PE,United Kingdom

‡ Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India

§ Dr. Reddy’s Laboratories SA Elisabethenanlage, 11CH-4051 Basel, Switzerland

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.6b00215

Publication Date (Web): July 05, 2016

Copyright © 2016 American Chemical Society

*E-mail: keholt.tiffin@drreddys.com.

http://pubs.acs.org/doi/full/10.1021/acs.oprd.6b00215

Dehydroepiandrosterone (DHEA, 2) is an important endogenous steroid hormone in mammals used in the treatment of a variety of dysfunctions in female and male health,1 as well as an intermediate in the synthesis of steroidal drugs, such as abiraterone acetate which is used for the treatment of prostate cancer.2−4 In this manuscript we describe a novel, concise, and cost-efficient route toward DHEA (2) and DHEA acetate (3) from 4-androstene-3,17-dione (4-AD, 1). Crucial to success was the identification of a ketoreductase from Sphingomonas wittichii for the highly regio- and stereoselective reduction of the C3-carbonyl group of 5-androstene-3,17-dione (5) to the required 3β-alcohol (2, >99% de). The enzyme displayed excellent robustness and solvent stability under high substrate concentrations (up to 150 g/L).

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