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Cinacalcet Hydrochloride spectral data

 


IR (KBr) (cm^–1): 3447, 2964, 1587, 800, 776. 


MS: m/z = 358.3 [M + H] ⁺.




¹H NMR (CDCl₃): δ 1.98 (d, J = 6.7 Hz, 3H), 2.2–2.35 (m, 2H), 2.46–2.60 (m, 2H), 2.55–2.85 (m, 2H), 5.10–5.25 (m, 1H), 7.16–7.26 (m, 3H), 7.31–7.33 (d, J = 7.4 Hz 1H), 7.54–7.65 (m, 3H), 7.88–7.97 (m, 3H), 8.23 (d, J = 7.2 Hz,1H). 

  
¹³C NMR (DMSO-d₆): δ 19.99 (CH₃), 27.01 (CH₂), 31.50 (CH₂), 44.65 (CH₂), 52.05 (CH), 122.58, 122.69, 122.73, 124.42, 124.74, 124.67, 125.50, 126.10, 126.88, 128.83, 128.89, 129.32, 130.28, 132.39, 133.32, 134.10, 142.25.
 http://pubs.acs.org/doi/full/10.1021/op300164y


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next set
  IR (KBr): 3427 (broad, –NH–), 2951, 2797, 2750, 2712, 1587, 1450, 1327, 1165, 1128, 1072, 798, 775 cm⁻¹;  

¹H NMR (DMSO-d₆/TMS) δ 1.67 (d, J = 6.6, 3H, –CH₃), 1.99 (quintet, 2H, –CH₂), 2.70 (m, 2H, –CH₂), 2.93 (m, 2H, –CH₂), 5.30 (q, 1H, –CH), 7.46–7.61 (m, 7H, ArH), 7.95–8.03 (m, 3H, ArH), 8.23 (d, J = 8.0, 1H, ArH), 9.36 (s, 1H, –NH) and 10.04 (s, 1H, HCl); 

 ¹³C NMR (DMSO-d₆/TMS) δ 142.61, 134.48, 133.70, 132.80, 130.64, 129.74, 129.58,129.28, 127.29, 126.54, 125.90, 125.08, 124.67, 123.16, 122.98, 52.37, 45.04, 31.84, 27.44, 20.30; 

MS m/z: 358 [M + 1]⁺.
http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-158

...........................
 IR (KBr) cm⁻¹: 3436, 2962, 2797, 1587, 1450, 1379, 1327, 1166, 1129, 797, 774, 746; 
MS: m/z = 358.79 [M + H] ⁺;  
¹H NMR (400 MHz, DMSO-d₆): δ = 1.67−1.69 (d, 3H), 1.97−2.02 (m, 2H), 2.67−2.69 (t, 4H), 5.27 (q, 1H), 7.44−7.46 (m, 4H), 7.54−7.61 (m, 3H), 7.93−7.99 (m, 2H), 8.026−8.08 (d, J = 7.2 Hz, 1H), 8.20−8.23 (d, J = 7.2 Hz, 1H), 9.46 (s, 1H), 10.17 (s, 1H);  
¹³C NMR (100 MHz, DMSO-d₆): δ = 20.49 (CH₃), 27.50 (CH₂), 32.02 (CH₂), 45.18 (CH₂), 52.60 (CH), 123.06, 123..23, 123.26, 124.94, 125.17, 125.21 (CF₃), 126.0, 126.60, 127.39, 129.35, 129.39, 129.82, 130.79, 132.88, 133.83, 134.58, 142.75; 
Anal. Calcd for C₂₂H₂₃NF₃Cl: C, 67.09; H, 5.84; N, 3.55; Found: C, 66.92; H, 5.68; N, 3.58.
 http://pubs.acs.org/doi/full/10.1021/op200016a

RABEPRAZOLE SPECTRAL DATA

SPECTRAL DATA FOR RABEPRAZOLE SODIUM
EP 1869015 B1
 IR Spectra (KBr, cm^-1): 3382, 2927, 1583, 1462, 1384, 1298, 1269, 1190, 1157, 1093, 1018, 745.

H NMR Spectra [200 M Hz, CD3OD] δ (ppm): 8.23 – 8.25 (1H, d, ArH); 7.57 – 7.62 (2H, m, ArH); 7.0 – 7.09 (2H, m, ArH); 6.87 – 6.90 (1H, d, ArH); 4.57 – 4.63 (2H, d, O=S-CH2-Ar); 4.0 – 4.1 (2H, t, -O-CH2-CH2-); 3.49 – 3.55 (2H, t, -CH2-O-CH3); 3.31 (3H, s, -OCH3); 2.1 (3H, s, Ar-CH3); 1.96 – 2.0 (2H, t, -CH2-CH2-CH2-).
.......................................................

¹H NMR (300 MHz, DMSO-d6) δ (ppm): 8.26-8.24 (d, 1H); 7.48-7.44 (m, 2H); 6.92-6.87 (m, 3H); 4.70-4.66 (d, 1H); 4.45-4.41 (d, 1H); 4.09-4.05 (t, 2H); 3.48-3.44 (t, 2H); 3.23 (s, 3H); 2.14 (s, 3H); 1.99-1.93 (q, 2H).
 US 8143409 B2
...........................................................


ONE MORE SOURCE FOR SODIUM RABEPRAZOLE DATA http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf

 IR (KBr, cm-1) 3047 (Ar-H), 2881(Ali-H), 1583 (aromatic
C=C), 1298 (C-N), 1093 (C-O arylalkylether),1027 (S-O,sulphoxide), 745 (Ar-H bending);

MS( ESI)+ve: 382(M++Na);

1H NMR (400MHz, DMSO-d6:
8.44 (d, J=5.6
Hz, 1H), 7.64-7.66 (m, 2H), 7.08-7.10 (m, 3H), 4.60-4.86
(dd, J=13.6, 2H), 4.25 (t, J=6.4 Hz, 2H), 3.64 (t, J=6.4Hz,
2H), 3.40 (s, 3H), 2.31 (s, 3H), 2.13 (qn, J=6.4, 2H).

13CNMR (100 MHz, DMDO-d6) 162.67, 154.68, 150.35,
147.69, 121.40, 119.79, 117.38, 110.49, 106.27, 68.31,
65.09, 57.95, 36.25, 28.68, 10.36.
 .......................................................

 1H NMR (CDCl3
+DMSO) of Rabeprazole sodium (1): δ 2.1 (m, 2H –CH2-), 2.2 (s, 3H, -
CH3), 3.3 (s, 3H, -OCH3), 3.6 (t, 2H, -OCH2-), 4.1 (t, 2H,-CH2-OCH3), 4.5 (d, Ha, -CH2-
pyridine), 4.7 (d, Hb, -CH2-pyridine), 6.6 (d, 1H, 1H-pyridine), 7.1-7.6 (m, 4H, Ar-H),
8.2 (d, 1H, pyridine). http://rasayanjournal.co.in/vol-1/issue-1/21.pdf
.....



 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf  ...........GET IR, NMR GRAPHS FOR RABEPRAZOLE SODIUM HERE

 .....................................................................





......................................................................
SPECTRAL DATA FOR RABEPRAZOLE (WITHOUT SODIUM)

IR (KBr, cm-1) 3064 (Ar-H), 2898(Ali-H), 1581 (aromatic
C=C), 1300 (C-N), 1095 (C-O arylalkylether),1060 (S-O,
sulphoxide), 753 (Ar-H bending);

MS( ESI)+ve: 360(M++1);

1H NMR (400MHz, DMSO-d6: 12.98 (brs, NH),8.28 (d, J=5.6 Hz, 1H), 7.69-7.61 (m, 3H), 6.70 (d, 2H),4.69-4.82 (dd, J=13.6, 2H), 4.05 (t, J=6.4 Hz, 2H), 3.51 (t,J=6.4Hz, 2H), 3.38 (s, 3H), 2.13 (s, 3H), 2.05 (qn, J=6.4,2H).

13C NMR (100 MHz, DMDO-d6)
163.68, 153.14,149.12, 148.22, 122.87, 119.74, 117.40, 110.50, 106.19,
68.74, 65.12, 58.75, 36.27, 29.21, 11.05.



 READ
http://jocpr.com/vol4-iss1-2012/JCPR-2012-4-1-130-139.pdf
 http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf
 http://www.ncbi.nlm.nih.gov/pubmed/17945453
 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf
 http://rasayanjournal.co.in/vol-1/issue-1/21.pdf




LATUR, MAHARASHTRA, INDIA

http://en.wikipedia.org/wiki/Latur

Latur लातूर Lattalur, Ratnapur
City
Latur Location in Maharashtra, India
Coordinates: 18.40°N 76.56°ECoordinates: 18.40°N 76.56°E
Country	India
State	Maharashtra
Region	Aurangabad Division
District	Latur
Settled	Possibly 7th century AD
Government
• Body	Latur Municipal Corporation
• Mayor	Akhtar Shaikh
Area[1]
• Total	117.78 km2(45.48 sq mi)
Area rank	89
Elevation	515 m (1,690 ft)
Population (2011)
• Total	382,754
• Rank	89th
• Density	3,200/km2(8,400/sq mi)
Demonym	Laturkar
Languages
• Official	Marathi
Time zone	IST (UTC+5:30)
PIN	413 512 413 531
Telephone code	91-2382
Vehicle registration	MH-24
Sex ratio	923.54 ♀/1000 ♂
Literacy	89.67
Distance from Mumbai	497 kilometres (309 mi) E (land)
Distance fromHyderabad	337 kilometres (209 mi) NW (land)
Distance fromAurangabad, Maharashtra	294 kilometres (183 mi) SE (land)
Climate	BSh (Köppen)
Precipitation	666 millimetres (26.2 in)
Avg. summer temperature	41 °C (106 °F)
Avg. winter temperature	13 °C (55 °F)
http://www.citypopulation.de/world/Agglomerations.html

his Is The Famous 'Ganj-Golai' As The Central Place Of The Latur City. There Are 16 Roads Connecting To This Place And Seperate Markets i.e. Jewellers ...




लातूर जिल्हयातील चित्र संग्रह

1. Colleges and Universities
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   Rajarshi Shahu College...

   

   Government Medical College...

   

   M. S. Bidve Engineering College...

   

   Mahatma Basweshwar College L...

   

   Dayanand Pharmacy College L...

LATUR AIRPORT

LATUR AIRPORT













2012 Navratri Mahotsav in Latur





SOS Children's Village Latur











Latur, India: Carnival Resort









Ausa Near Latur







Chakur near Latur



Vilasrao Deshmukh's ancestral home at Babhalgaon village in Latur. Machindra Amle

















UDGIR: Udgir is one of the most important towns of Latur district. Udgir has a great historical significance. It has witnessed the war between the Marathas ...







The city of Latur is located in India's welathiest state, Maharashtra. Together with many of the surrounding villages, Latur was all but destroyed in the