SPECTRAL DATA FOR RABEPRAZOLE SODIUM
EP 1869015 B1
IR Spectra (KBr, cm-1): 3382, 2927, 1583, 1462, 1384, 1298, 1269, 1190, 1157, 1093, 1018, 745.
H NMR Spectra [200 M Hz, CD3OD] δ (ppm): 8.23 – 8.25 (1H, d, ArH); 7.57 – 7.62 (2H, m, ArH); 7.0 – 7.09 (2H, m, ArH); 6.87 – 6.90 (1H, d, ArH); 4.57 – 4.63 (2H, d, O=S-CH2-Ar); 4.0 – 4.1 (2H, t, -O-CH2-CH2-); 3.49 – 3.55 (2H, t, -CH2-O-CH3); 3.31 (3H, s, -OCH3); 2.1 (3H, s, Ar-CH3); 1.96 – 2.0 (2H, t, -CH2-CH2-CH2-).
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1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.26-8.24 (d, 1H); 7.48-7.44 (m, 2H); 6.92-6.87 (m, 3H); 4.70-4.66 (d, 1H); 4.45-4.41 (d, 1H); 4.09-4.05 (t, 2H); 3.48-3.44 (t, 2H); 3.23 (s, 3H); 2.14 (s, 3H); 1.99-1.93 (q, 2H).
US 8143409 B2
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ONE MORE SOURCE FOR SODIUM RABEPRAZOLE DATA http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf
IR (KBr, cm-1) 3047 (Ar-H), 2881(Ali-H), 1583 (aromatic
C=C), 1298 (C-N), 1093 (C-O arylalkylether),1027 (S-O,sulphoxide), 745 (Ar-H bending);
MS( ESI)+ve: 382(M++Na);
1H NMR (400MHz, DMSO-d6:
8.44 (d, J=5.6
Hz, 1H), 7.64-7.66 (m, 2H), 7.08-7.10 (m, 3H), 4.60-4.86
(dd, J=13.6, 2H), 4.25 (t, J=6.4 Hz, 2H), 3.64 (t, J=6.4Hz,
2H), 3.40 (s, 3H), 2.31 (s, 3H), 2.13 (qn, J=6.4, 2H).
13CNMR (100 MHz, DMDO-d6) 162.67, 154.68, 150.35,
147.69, 121.40, 119.79, 117.38, 110.49, 106.27, 68.31,
65.09, 57.95, 36.25, 28.68, 10.36.
.......................................................
1H NMR (CDCl3
+DMSO) of Rabeprazole sodium (1): δ 2.1 (m, 2H –CH2-), 2.2 (s, 3H, -
CH3), 3.3 (s, 3H, -OCH3), 3.6 (t, 2H, -OCH2-), 4.1 (t, 2H,-CH2-OCH3), 4.5 (d, Ha, -CH2-
pyridine), 4.7 (d, Hb, -CH2-pyridine), 6.6 (d, 1H, 1H-pyridine), 7.1-7.6 (m, 4H, Ar-H),
8.2 (d, 1H, pyridine). http://rasayanjournal.co.in/vol-1/issue-1/21.pdf
.....
http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf ...........GET IR, NMR GRAPHS FOR RABEPRAZOLE SODIUM HERE
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SPECTRAL DATA FOR RABEPRAZOLE (WITHOUT SODIUM)
IR (KBr, cm-1) 3064 (Ar-H), 2898(Ali-H), 1581 (aromatic
C=C), 1300 (C-N), 1095 (C-O arylalkylether),1060 (S-O,
sulphoxide), 753 (Ar-H bending);
MS( ESI)+ve: 360(M++1);
1H NMR (400MHz, DMSO-d6: 12.98 (brs, NH),8.28 (d, J=5.6 Hz, 1H), 7.69-7.61 (m, 3H), 6.70 (d, 2H),4.69-4.82 (dd, J=13.6, 2H), 4.05 (t, J=6.4 Hz, 2H), 3.51 (t,J=6.4Hz, 2H), 3.38 (s, 3H), 2.13 (s, 3H), 2.05 (qn, J=6.4,2H).
13C NMR (100 MHz, DMDO-d6)
163.68, 153.14,149.12, 148.22, 122.87, 119.74, 117.40, 110.50, 106.19,
68.74, 65.12, 58.75, 36.27, 29.21, 11.05.
READ
http://jocpr.com/vol4-iss1-2012/JCPR-2012-4-1-130-139.pdf
http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf
http://www.ncbi.nlm.nih.gov/pubmed/17945453
http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf
http://rasayanjournal.co.in/vol-1/issue-1/21.pdf
LATUR, MAHARASHTRA, INDIA
http://en.wikipedia.org/wiki/Latur
| Latur लातूर Lattalur, Ratnapur | |
|---|---|
| City | |
 
Latur
| |
| Coordinates: 18.40°N 76.56°ECoordinates: 18.40°N 76.56°E | |
| Country |  India |
| State | Maharashtra |
| Region | Aurangabad Division |
| District | Latur |
| Settled | Possibly 7th century AD |
| Government | |
| • Body | Latur Municipal Corporation |
| • Mayor | Akhtar Shaikh |
| Area[1] | |
| • Total | 117.78 km2(45.48 sq mi) |
| Area rank | 89 |
| Elevation | 515 m (1,690 ft) |
| Population (2011) | |
| • Total | 382,754 |
| • Rank | 89th |
| • Density | 3,200/km2(8,400/sq mi) |
| Demonym | Laturkar |
| Languages | |
| • Official | Marathi |
| Time zone | IST (UTC+5:30) |
| PIN |
|
| Telephone code | 91-2382 |
| Vehicle registration | MH-24 |
| Sex ratio | 923.54 ♀/1000 ♂ |
| Literacy | 89.67 |
| Distance from Mumbai | 497 kilometres (309 mi) E (land) |
| Distance fromHyderabad | 337 kilometres (209 mi) NW (land) |
| Distance fromAurangabad, Maharashtra | 294 kilometres (183 mi) SE (land) |
| Climate | BSh (Köppen) |
| Precipitation | 666 millimetres (26.2 in) |
| Avg. summer temperature | 41 °C (106 °F) |
| Avg. winter temperature | 13 °C (55 °F) |
| http://www.citypopulation.de/world/Agglomerations.html | |
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