RABEPRAZOLE

1H NMR RABEPRAZOLE

RAB standard: (DMSOd6 400 MHz) δ 8.28 (d, 1H, J=5.56 Hz), 7.46 (m, 2H), 6.93 (d, 1H, J=5.68 Hz), 6.88 (m, 2H), 4.57 (AB, 2H, J=12.88 Hz), 4.10 (t, 2H, J=6.19 Hz), 3.49 (t, 2H, J=6.32 Hz), 3.25 (S, 3H), 2.17 (S, 3H), 1.98 (quin., 2H, J=6.19 Hz) 13C NMR (DMSOd6, 101 MHz) δ 162.61, 152.41, 147.95, 146.62, 121.74, 118.20, 117.32, 105.92, 68.30, 64.92, 59.64, 57.96, 28.67, 10.83.

The 1H spectrum for the RAB starting material is shown with peaks labelled and integrated. Data were collected on a 400 MHz NMR in DMSOd6, corrected to TMS by residual non-deuterated solvent.

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Figure S13 COSY NMR spectrum of RAB

The COSY spectrum for the RAB starting material is shown. This was used to assign the methoxypropoxy carbon chain δ 1.98, 3.49 and 4.10. Data were collected on a 400 MHz NMR in DMSOd6, corrected to TMS by residual non-deuterated solvent.

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Figure S14 HMBC spectrum of RAB

The spectrum shows the long range coupling of 1H to 13C nuclei. Coupling is observed between the 3-methyl group and the AB system, and between the various hydrogens on the alkyl chain.

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RABEPRAZOLE SPECTRAL DATA

SPECTRAL DATA FOR RABEPRAZOLE SODIUM
EP 1869015 B1
 IR Spectra (KBr, cm^-1): 3382, 2927, 1583, 1462, 1384, 1298, 1269, 1190, 1157, 1093, 1018, 745.

H NMR Spectra [200 M Hz, CD3OD] δ (ppm): 8.23 – 8.25 (1H, d, ArH); 7.57 – 7.62 (2H, m, ArH); 7.0 – 7.09 (2H, m, ArH); 6.87 – 6.90 (1H, d, ArH); 4.57 – 4.63 (2H, d, O=S-CH2-Ar); 4.0 – 4.1 (2H, t, -O-CH2-CH2-); 3.49 – 3.55 (2H, t, -CH2-O-CH3); 3.31 (3H, s, -OCH3); 2.1 (3H, s, Ar-CH3); 1.96 – 2.0 (2H, t, -CH2-CH2-CH2-).
.......................................................

¹H NMR (300 MHz, DMSO-d6) δ (ppm): 8.26-8.24 (d, 1H); 7.48-7.44 (m, 2H); 6.92-6.87 (m, 3H); 4.70-4.66 (d, 1H); 4.45-4.41 (d, 1H); 4.09-4.05 (t, 2H); 3.48-3.44 (t, 2H); 3.23 (s, 3H); 2.14 (s, 3H); 1.99-1.93 (q, 2H).
 US 8143409 B2
...........................................................


ONE MORE SOURCE FOR SODIUM RABEPRAZOLE DATA http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf

 IR (KBr, cm-1) 3047 (Ar-H), 2881(Ali-H), 1583 (aromatic
C=C), 1298 (C-N), 1093 (C-O arylalkylether),1027 (S-O,sulphoxide), 745 (Ar-H bending);

MS( ESI)+ve: 382(M++Na);

1H NMR (400MHz, DMSO-d6:
8.44 (d, J=5.6
Hz, 1H), 7.64-7.66 (m, 2H), 7.08-7.10 (m, 3H), 4.60-4.86
(dd, J=13.6, 2H), 4.25 (t, J=6.4 Hz, 2H), 3.64 (t, J=6.4Hz,
2H), 3.40 (s, 3H), 2.31 (s, 3H), 2.13 (qn, J=6.4, 2H).

13CNMR (100 MHz, DMDO-d6) 162.67, 154.68, 150.35,
147.69, 121.40, 119.79, 117.38, 110.49, 106.27, 68.31,
65.09, 57.95, 36.25, 28.68, 10.36.
 .......................................................

 1H NMR (CDCl3
+DMSO) of Rabeprazole sodium (1): δ 2.1 (m, 2H –CH2-), 2.2 (s, 3H, -
CH3), 3.3 (s, 3H, -OCH3), 3.6 (t, 2H, -OCH2-), 4.1 (t, 2H,-CH2-OCH3), 4.5 (d, Ha, -CH2-
pyridine), 4.7 (d, Hb, -CH2-pyridine), 6.6 (d, 1H, 1H-pyridine), 7.1-7.6 (m, 4H, Ar-H),
8.2 (d, 1H, pyridine). http://rasayanjournal.co.in/vol-1/issue-1/21.pdf
.....



 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf  ...........GET IR, NMR GRAPHS FOR RABEPRAZOLE SODIUM HERE

 .....................................................................





......................................................................
SPECTRAL DATA FOR RABEPRAZOLE (WITHOUT SODIUM)

IR (KBr, cm-1) 3064 (Ar-H), 2898(Ali-H), 1581 (aromatic
C=C), 1300 (C-N), 1095 (C-O arylalkylether),1060 (S-O,
sulphoxide), 753 (Ar-H bending);

MS( ESI)+ve: 360(M++1);

1H NMR (400MHz, DMSO-d6: 12.98 (brs, NH),8.28 (d, J=5.6 Hz, 1H), 7.69-7.61 (m, 3H), 6.70 (d, 2H),4.69-4.82 (dd, J=13.6, 2H), 4.05 (t, J=6.4 Hz, 2H), 3.51 (t,J=6.4Hz, 2H), 3.38 (s, 3H), 2.13 (s, 3H), 2.05 (qn, J=6.4,2H).

13C NMR (100 MHz, DMDO-d6)
163.68, 153.14,149.12, 148.22, 122.87, 119.74, 117.40, 110.50, 106.19,
68.74, 65.12, 58.75, 36.27, 29.21, 11.05.



 READ
http://jocpr.com/vol4-iss1-2012/JCPR-2012-4-1-130-139.pdf
 http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf
 http://www.ncbi.nlm.nih.gov/pubmed/17945453
 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf
 http://rasayanjournal.co.in/vol-1/issue-1/21.pdf




LATUR, MAHARASHTRA, INDIA

http://en.wikipedia.org/wiki/Latur

Latur लातूर Lattalur, Ratnapur
City
Latur Location in Maharashtra, India
Coordinates: 18.40°N 76.56°ECoordinates: 18.40°N 76.56°E
Country	India
State	Maharashtra
Region	Aurangabad Division
District	Latur
Settled	Possibly 7th century AD
Government
• Body	Latur Municipal Corporation
• Mayor	Akhtar Shaikh
Area[1]
• Total	117.78 km2(45.48 sq mi)
Area rank	89
Elevation	515 m (1,690 ft)
Population (2011)
• Total	382,754
• Rank	89th
• Density	3,200/km2(8,400/sq mi)
Demonym	Laturkar
Languages
• Official	Marathi
Time zone	IST (UTC+5:30)
PIN	413 512 413 531
Telephone code	91-2382
Vehicle registration	MH-24
Sex ratio	923.54 ♀/1000 ♂
Literacy	89.67
Distance from Mumbai	497 kilometres (309 mi) E (land)
Distance fromHyderabad	337 kilometres (209 mi) NW (land)
Distance fromAurangabad, Maharashtra	294 kilometres (183 mi) SE (land)
Climate	BSh (Köppen)
Precipitation	666 millimetres (26.2 in)
Avg. summer temperature	41 °C (106 °F)
Avg. winter temperature	13 °C (55 °F)
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his Is The Famous 'Ganj-Golai' As The Central Place Of The Latur City. There Are 16 Roads Connecting To This Place And Seperate Markets i.e. Jewellers ...




लातूर जिल्हयातील चित्र संग्रह

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LATUR AIRPORT

LATUR AIRPORT













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Vilasrao Deshmukh's ancestral home at Babhalgaon village in Latur. Machindra Amle

















UDGIR: Udgir is one of the most important towns of Latur district. Udgir has a great historical significance. It has witnessed the war between the Marathas ...







The city of Latur is located in India's welathiest state, Maharashtra. Together with many of the surrounding villages, Latur was all but destroyed in the