DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Sunday, 23 November 2014

The Cocaine Diastereoisomers




Table 1.
Melting point data °C.
Compound
Findlay4
Sinnema
et al.
5
Willstätter
et al.
7
Merck9
This
Work
(-)-Cocaine
-
-
-
98
96-97
(+)-Cocaine
-
-
98
-
-
(±)-Cocaine
79-80
-
79-80
-
74-75
(-)-Cocaine HCl
-
-
192
195
194-196
(±)-Cocaine HCl
187
-
187
-
186-188
(+)-Pseudococaine
-
-
43-45
47
-
(±)-Pseudococaine
81.5
-
81.5
-
oil
(+)-Pseudococaine HCl
-
-
205
210
208-210
(±)-Pseudococaine HCl
205.5
-
205-206
-
202-204
(±)-Allococaine
93-95
95-97
-
-
94-96
(±)-Allococaine HCl
oil
oil
-
-
oil
(±)-Pseudoallococaine
82-84
83-84
-
-
oil
(±)-Pseudoallococaine HCl
201.5
209-210
-
-
203-205
\\\

Proton Nuclear Magnetic Resonance
1H-NMR Spectra
(in CDCl3)
Fig. 4.Cocaine
Fig. 5.Pseudococaine
Fig. 6.Allococaine
Fig. 7.Pseudoallococaine
Proton NMR spectra of the diastereoisomeric cocaines are significantly different. Major differences are seen in the chemical shifts associated with the respective C-3 protons. In addition, the coupling patterns that arise from the vicinal coupling of C-2 and C-4 protons with the C-3 proton are first order and relate nicely to the Karplus equation5.
That the diastereoisomeric cocaines, can easily be distinguished by observation of the chemical shifts and coupling patterns associated with the C-3 proton does not imply that other differences do not exist. In fact, virtually every proton in these molecules exhibits a different chemical shift or coupling pattern

COCAINE














  1. Findlay, S. P., J. Am. Chem. Soc., 76, 2855-2862 (1954)
  2. Findlay, S. P., J. Org. Chem., 21, 711 (1956)
  3. Findlay, S. P., J. Org. Chem., 22, 1385-1394 (1957)
  4. Findlay, S. P., J. Org. Chem., 24, 1540-1550 (1959)
  5. A. Sinnema, L Maat, AJ vd.Gugten, HC Beyerman, Rec. Trav. Chim. Pays-Bas 87, 1027-1041 (1968)
  6. Robinson, R., Journal of the Chemical Society (London), 111, 762-768 (1917)
  7. Willstätter, R., Wolfes, O., and Mäder, H., Justus Liebigs Annalen der Chemie, 434, 111-139 (1923)
  8. Fulton, C. C., Modern Microcrystal Tests for Drugs, Wiley, New York, 1969, pp. 21-24.
  9. The Merck Index, 9th ed., 1976, Merck and Co., Rahway, N.J.
  10. Fulton, C. C., Modern Microcrystal Test for Drugs, Wiley, New York, 1969, pp. 318-19.
  11. Clarke, E. G. C., Isolation and Identification of Drugs, Pharmaceutical Press, London, 1971, pp. 139-41.
  12. Fulton, C. G., Modern Microcrystal Tests for Drugs, Wiley, New York, 1969, p. 301.
  13. Cooper, D. A. and Allen, A. C., "A Mechanistic Interpretation of the Mass Spectrum of Cocaine",
    31st Annual Meeting of the American Academy of Forensic Sciences, Atlanta, Georgia, Feb. 1979.
  14. Eliel, E. L., Stereochemistry of Carbon Compounds, McGraw-Hill, New York, 1962, pp. 43-47.




DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO

http://newdrugapprovals.org/

12 comments:

  1. Tel chem shop we provide you with cheap drugs. While discount costs on medication is our main focus, we are still committed to ensuring the safety and quality of all medicine that is dispensed from our partner pharmacies. telchemshop.com places you in touch with the best prices the various world pharmacies have to offer. Each of our partner pharmacies were specially selected for their commitment to the services provided as well as the cheap prices they offered on your prescription medication. Each prescription drug that is ordered still requires a valid prescription written by a doctor.

    Buy Ethylone Online

    Buy Mexedrone Online

    Buy MDPV Online

    Buy Bk-2C-B Online

    Buy A-PVP Online

    Buy Etizolam online

    Buy Lyrica online

    Buy Ambien Online

    Buy Demerol Online

    Buy Fentanyl Online

    Contact us: + 447418334351

    Buy 4-Fluoroamphetamine online

    methylone wholesale

    2c t 2 buy online

    hollandia truffles

    buy 3.5g social cocaine

    ethylone crystal for sale

    buy 2c-t-2 online

    Website : telchemshop.com

    mmc online

    4 aco met buy

    buy mmc shop

    4 mmc shop for sale

    Buy 4F-PHP Crystals Powder online

    Buy 4 MMC powder online

    Buy 4-Aco-DMT powder online

    Buy Ephedrine Hcl Online

    Email ID: info@telchemshop.com

    ReplyDelete
  2. Best medicine (medicine oceans) supplier phone- +1(252)228-4229
    https://www.medicineoceans.com/product/buy-adderall-online/
    We are specialized in supplying oxycodone in all dosage forms and types. We supply several other products such as Oxycontin, Hydrocodone and many more.Our main objective is to satisfy our customers and we only supply FDA approved medications. We have a well trained team of workers available at all times and ready to meet customer needs and answer all customer questions.

    Reach out to us->
    Email Address
    Email: info@medicineoceans.com
    WhatsApp / Call / SMS:
    +1 (252) 228-4229

    ReplyDelete


  3. Best Medicine (Lapsta pharmacy) supplier phone-+1 (424) 209-8290

    https://lapstapharmacy.com/product-category/opioids/
    Best medicines with approximately 5-15% lower market price than other distributors.
    In keeping fully abreast of developments and innovations in the market, all of your-med.com projects are supported by the most advanced systems available. We are skilled and experienced professionals in this field and have set ourselves the target of becoming one of the world’s leading and most reputable online providers of pharmaceuticals.


    • DEPRESSANTS AND ANXIETY
    • ANABOLIC STEROIDS
    • HALLUCINOGENS
    • STIMULANTS
    • OPIOIDS
    • Oxycodone
    • Uncategorized
    • Xanax

    • Get In Touch
    • Phone : +1 (424) 209-8290
    • Email : info@lapstapharmacy.com
    • Website :https://lapstapharmacy.com


    ReplyDelete
  4. Best Medicine Supplier (Recreational marijuana shops) Supplier Phone-+1(720) 515-4677
    https://recreationalmarijuanashops.com/product/afghan-kush/
    We are strong believers that every patient who requires medical marijuana should have easy access to it. We want to do everything in our power to make sure that these patients get the very best access to the very best medical marijuana that We have to offer.
    Recreational Marijuana Shop is committed to ensuring that your privacy and security is protected at all times
    PRODUCTS TO OFFER-
    Grizzly genetics
    Top grinder
    Acapula gold
    Afghan kush
    Afghani Hawaiian
    Alaskan thunder

    Get in touch
    Phone-+1(720) 515-4677
    Email- info@recreationalmarijuanashops.com


    ReplyDelete
  5. Best medicine (medicine oceans) supplier phone- +1(252)228-4229
    https://www.medicineoceans.com/product/buy-adipex-p-online/
    We are specialized in supplying oxycodone in all dosage forms and types. We supply several other products such as Oxycontin, Hydrocodone and many more.Our main objective is to satisfy our customers and we only supply FDA approved medications. We have a well trained team of workers available at all times and ready to meet customer needs and answer all customer questions.

    Reach out to us->
    Email Address
    Email: info@medicineoceans.com
    WhatsApp / Call / SMS:
    +1 (252) 228-4229

    ReplyDelete
  6. Best Medicine (Royal Pharmaceutical) Supplier Phone-+1 (415) 480-4502
    https://www.royal-pharmaceutical.com/product/acetaminophen-300mg/
    Quality Research Chemicals was founded in October of 2016 and was created with the sole mission and dedication “To provide the highest quality research chemical and pill products on the market with the best customer service in the industry”.
    Our products are 100% genuine and our prices are some of the best in the vape world. If your looking for the newest and best research chemicals on the internet then you have found it right here.

    Get in touch->
    Phone number-+1 (415) 480-4502

    ReplyDelete
  7. Best Medicine Supplier (Recreational marijuana shops) Supplier Phone-+1(720) 515-4677
    https://recreationalmarijuanashops.com/product/acapula-gold/
    We are strong believers that every patient who requires medical marijuana should have easy access to it. We want to do everything in our power to make sure that these patients get the very best access to the very best medical marijuana that We have to offer.
    Recreational Marijuana Shop is committed to ensuring that your privacy and security is protected at all times
    PRODUCTS TO OFFER-
    Grizzly genetics
    Top grinder
    Acapula gold
    Afghan kush
    Afghani Hawaiian
    Alaskan thunder

    Get in touch
    Phone-+1(720) 515-4677
    Email- info@recreationalmarijuanashops.com


    ReplyDelete
  8. Best Medicines (Ritalin) Supplier Phone- +1 (213)-373-6580
    https://ritalinbuy.com/product/%e4%b9%b0-percocet-%e5%9c%a8%e7%ba%bf/

    The best AOL pharmacy with 100% successful delivery
    The core of our approach is truly patient-centric. This is better than putting patients first

    We believe that when people consult with healthcare professionals, they have all the options available. No one should not be able to obtain the latest scientific and medical breakthroughs because of geographic location.



    Contact us->
    Phone no- +1 (213)-373-6580
    Email- info@ritalinbuy.com

    ReplyDelete
  9. Oxycodone broadened discharge containers or tablets ought not be utilized in the event that you need agony drug for only a brief span, for example, when recouping from medical procedure Oxycodone broadened discharge containers or tablets ought not be utilized in the event that you need agony drug for only a brief span
    Related searches
    buy hydrocodone online
    buy DILAUDID online
    Buy percocet online
    Call or text +1-858 753 9237 only for usa

    ReplyDelete

  10. Buy Best Medicines from (Lapsta pharmacy) supplier phone-+1 (424) 209-8290
    https://lapstapharmacy.com/product/cypionate/

    Best medicines with high discounts as compared to other manufactures..
    In keeping fully knowledge of developments and innovations in the market, all of your-med.com projects are supported by the most advanced systems available.
    We are developed and experienced professionals in this field and have set ourselves the target of becoming one of the world’s leading and most reputable online providers of pharmaceuticals.


    • DEPRESSANTS AND ANXIETY
    • ANABOLIC STEROIDS
    • HALLUCINOGENS
    • STIMULANTS
    • OPIOIDS
    • Oxycodone
    • Uncategorized
    • Xanax
    buy RITALIN CHINA
    buy vyvanse online
    BUY Greenstone Xanax ONLINE
    • <a href=" https://lapstapharmacy.com/”>Buy medicines at cheap rate</a>
    • <a href=”https://discoveryonlinepharmacy.com/”>Buy Medicines at great discount</a>



    • Get In Touch
    • Phone : +1 (424) 209-8290
    • Email : info@lapstapharmacy.com
    • Website :https://lapstapharmacy.com



    #medical medicalcompany #medicine #drugs #drugcompany #medicalequipments #healthcare #surgerical #medicalassistant #hospital

    ReplyDelete

  11. https://orgspectroscopyint.blogspot.com/2014/11/the-cocaine-diastereoisomers.html?showComment=1595915930144#c5235972215011009335

    ReplyDelete
  12. Your Article is no doubt very helpful for me and hope, also for the other visitors. I requested to maintain your standard. Thanks for publishing.

    Skip Hire Wolverhampton
    Skip Hire Edinburgh
    Skip Hire Barnsley
    Skip Hire Blackpool
    Skip Hire Warrington
    Skip Hire Wigan
    Skip Hire Burton
    Skip Hire Stockport

    ReplyDelete