A stereochemical perspective from endo and exocyclic chiral centres

Diastereoselective syntheses of 3-aryl-(S/R)-6-methyl-1-[(S/R)-1-phenylethyl)]-2-thioxotetrahydro pyrimidin-4(1H)-ones were achieved in good yields by the condensation of aryl isothiocyanates with ethyl 3-(1-phenylethylamino)butanoate in a one-pot reaction. Benzylationof these substrates illustrated that the orientations of the exocylic and endocylic groupsdetermine the stereochemical outcome of the product formed.

http://pubs.rsc.org/en/content/articlelanding/2010/ob/c0ob00230e#!divAbstract

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO

http://newdrugapprovals.org/