Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C-H) with indoles (sp2 C-H) using a heterogeneous mesoporous manganese oxide catalyst

Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C-H) with indoles (sp2 C-H) using a heterogeneous mesoporous manganese oxide catalyst

Green Chem., 2017, Advance Article
DOI: 10.1039/C7GC01919J, Communication

B. Dutta, V. Sharma, N. Sassu, Y. Dang, C. Weerakkody, J. Macharia, R. Miao, A. R. Howell, S. L. Suib
We disclose a novel, heterogeneous catalytic approach for selective coupling of C1 of N-aryltetrahydroisoquinolines with C3 of indoles in the presence of mesoporous manganese oxides.

Cross dehydrogenative coupling of N-aryltetrahydroisoquinolines (sp3 C–H) with indoles (sp2 C–H) using a heterogeneous mesoporous manganese oxide catalyst

B. Dutta,a  V. Sharma,b  N. Sassu,a  Y. Dang,c  C. Weerakkody,a  J. Macharia,a  R. Miao,a  A. R. Howella  and  S. L. Suib*ac 

 Author affiliations

*Corresponding authors

aDepartment of Chemistry, University of Connecticut, Storrs, USA
E-mail:steven.suib@uconn.edu

bMaterials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, USA

cInstitute of Materials Science, University of Connecticut, U-3060, 55 North Eagleville Rd., Storrs, USA

Biswanath Dutta

Ph.D Candidate

Chemistry

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B.Sc. Chemistry, University of Calcutta, India, 2011

M.S. Chemistry, IIT Bombay, India, 2013

Group Member Since 2013

Research Area: Material synthesis, Catalysis

Email	biswanath.dutta@uconn.edu

Steven Suib

Professor

Email	steven.suib@uconn.edu
Phone	(860) 486-2797
Fax	(860) 486-2981
Mailing Address	University of Connecticut Department of Chemistry 55 N. Eagleville Rd Storrs, CT 06269
Office Location	CHEM A-313

Abstract

We disclose a novel, heterogeneous catalytic approach for selective coupling of C1 of N-aryltetrahydroisoquinolines with C3 of indoles in the presence of mesoporous manganese oxides. Our work involves a detailed mechanistic investigation of the reaction on the catalyst surface, backed by DFT computational studies, to understand the superior catalytic activity of manganese oxides.

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