1,2,3-Trichloropropane

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 IR

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1,2,3-Trichloropropane(96-18-4)

 



 




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 Scheme 1.

(a) PPh₃, C₂Cl₆/TEA, toluene/reflux 2 h; (b) dry toluene, CS₂; (c) RCHO, ClCH₂COOH, fused CH₃COONa, reflux; (d) piperidine, THF, rt.

(Z)-2-Benzylidene-7-isocyano-3,6-dioxo-8-phenyl-3,6-dihydro-2H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile (4a)

White solid in a yield of 87%, mp 146–148 °C; IR (KBr, cm⁻¹): 3032 (Ar-H), 1730 (CO), 1590 (CN), ¹H NMR (300 MHz, DMSO-d₆): δ 8.20 (s, 1H, CH), 7.60–7.55 (m, 2H, Ar-H), 7.45–7.33 (m, 6H, Ar-H), 7.19–7.17 (m, 2H, Ar-H), LC–MS (m/z, %): 422 (M+1)⁺. Anal. Calcd for C₂₃H₁₁N₅O₂S: C, 64.25; H, 2.55; N, 16.57. Found: C, 65.55; H, 2.63; N, 16.62.

3-Hydroxy-7-isocyano-6-oxo-8-phenyl-2-(phenyl(piperidin-1-yl)methyl)-6H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile (5a)

Colorless crystals in a yield of 67%, mp 130–132 °C; IR (KBr, cm⁻¹): 3100 (O–H), 3030 (Ar-H), 2960 (C–H aliphatic), 1730 (CO), 1590 (CN), ¹H NMR (300 MHz, DMSO-d₆): 7.70–7.30 (m, 10H, Ar-H), 6.90 (s, 1H, CH), 3.7–3.22 (m, 4H, N(CH₂)₂), 1.7–1.4 (m, 6H, (CH₂)₃). LC–MS (m/z, %): 507 (M+1)⁺. Anal. Calcd for C₂₈H₂₂N₆O₂S: C, 66.93; H, 5.02; N, 16.95. Found: C, 66.39; H, 4.38; N, 16.59.

Arabian Journal of Chemistry

Volume 9, Issue 1, January 2016, Pages 136–142

Synthesis and pharmacological evaluation of novel 2H/6H-thiazolo-[3′,2′:2,3][1,2,4]triazolo[1,5-a]pyridine-9-carbonitrile derivatives

• Maddila Suresh,
• Palakondu Lavanya,
• Chunduri Venkata Rao^,

• Department of Chemistry, S.V. University, Tirupati 517502, India

doi:10.1016/j.arabjc.2011.02.004

 http://www.sciencedirect.com/science/article/pii/S1878535211000451

SURESH MADDILA

NRF-DST Innovation Post-Doctoral Research Scientist at University of KwaZulu Natal, West Ville Campus, Durban

 

NRF-DST Innovation Post-doctoral Research Scientist

University of Kwazulu Natal, WestVille Campus, Durban

January 2011 – Present (5 years 7 months)School of Chemistry & Physics., University of KwaZulu Natal, Durban

Currently, I am working as a NRF-DST Innovation Post-Doctoral Researcher at UKZN on temporary basis for a period of 1 month. I further extended my research by deriving the data from various syntheses of organic molecules, photocatalysis with ozone and synthesis of homogeneous & heterogeneous catalysts. The derived data has been compared and validated with the various spectroscopic techniques like 1H NMR, 13C NMR, MASS, IR spectroscopic data. In addition, I started my work towards middle homogeneous & heterogeneous photocatalysis and ozonation using different GC, XRD, SEM, TEM, BET, RAMAN, UV, UV-DRS, IR and spectrophotometers. The working group has been carried out under my investigation.

Teaching Assistant

Sri Venkateswara University, Tirupati, India.

August 2006 – October 2010 (4 years 3 months)

Inorganic, Organic Chemistry & Physical Chemistry, Spectroscopy and Environmental Science

 

 MOM WILL TEACH YOU NMR


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 Sinjar, Nineveh Province, Iraq
 SINJAR IRAQ

Sinjar

Town in Iraqi Kurdistan

Sindjar, also known as Shingal and formerly Sanjár, is a town in Sinjar District, Nineveh Province, Iraq near Mount Sinjar. Its population in 2013 was estimated at 88,023. Wikipedia

 

 

 

 

 
 
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2-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

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 2-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one


formula (I), 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ol (enol form; formula (Ia)) or 2-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one (keto form; formula (Ib)), is known from WO 2008/067871.

 sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, which corresponds to the compound of the formula (II)

• FIG. 1: IR spectra of the compound of the formula (II) and of the compound of the formula (I) 
   
• FIG. 2: Raman spectra of the compound of the formula (II) and of the compound of the formula (I)
   
• FIG. 3: UV/VIS spectra of the compound of the formula (II) and of the compound of the formula (I) 
   
• FIG. 5: ¹H NMR spectrum of the compound of the formula (I)

 

• FIG. 7: ¹³C NMR spectrum of the compound of the formula (I)

 

• FIG. 9: Mass spectrum of the compound of the formula (I)

 



 MOM WILL TEACH YOU NMR



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Jhang Sadar, Punjab, pakistan

 

Jhang Sadar

City in Pakistan

Jhang Sadar is a city in Punjab, Pakistan, situated by the Chenab River and 193 kilometres from Lahore, at 31.28 N latitude and 72.32 E longitude. The population of Jhang Sadar was calculated to be 354,248 in 2007. Wikipedia

 

 

 

 

 

 

 

 

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