VENLAFAXINE PART 3/3

SEE

part 1………http://orgspectroscopyint.blogspot.in/2015/04/venlafaxine.html  /  http://newdrugapprovals.org/2015/04/09/venlafaxine-part-12/

part 2……..http://newdrugapprovals.org/2015/04/09/venlafaxine-22/

PART 3…..http://orgspectroscopyint.blogspot.in/2015/04/venlafaxine-part-33.html

SEE ALSO

http://www.google.com/patents/WO2008059525A2?cl=en

PAPER

RSC Adv., 2014,4, 14468-14470

DOI: 10.1039/C4RA00840E

http://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra00840e#!divAbstract

A protecting group free asymmetric total synthesis of (−)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situgenerated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (−)-venlafaxine.

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JAFFNA SRILANKA