DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Tuesday, 23 September 2014

4-fluoro-N-((3R,4S)-3-hydroxy-6-(piperazin-1-yl)chroman-4-yl)benzamide

Inline image 1

4-fluoro-N-((3R,4S)-3-hydroxy-6-(piperazin-1-yl)chroman-4-yl)benzamide



HPLC purity = 97.3% (tR = 5.7 min) by HPLC method 2. ee = 100% at 4.68 min by Chiral HPLC method 2.

Specific rotation: [α]D20 = 23.02 (c = 10, 95% EtOH-5% H2O).

1H NMR (400 MHz, DMSO-d6) δ 8.75 (d, J = 8.2 Hz, 1H), 8.02–7.92 (m, 2H), 7.33–7.22 (m, 2H), 6.80 (dd, J = 8.9, 2.9 Hz, 1H), 6.71–6.60 (m, 2H), 5.36 (d, J = 3.9 Hz, 1H), 4.95 (dd, J = 8.2, 5.2 Hz, 1H), 4.12 (dd, J = 10.4, 1.8 Hz, 1H), 3.95–3.83 (m, 2H), 2.84–2.71 (m, 8H), 2.17 (s, 1H).


13C NMR (DMSO-d6, 100 MHz): δ 165.6, 163.1, 148.3, 146.7, 131.3, 130.7, 122.2, 118.2, 117.3, 116.8, 115.4, 67.5, 66.2, 51.5, 46.1, 40.8.


HRMS (ESI+): calcd. for C20H22FN3O3 (M+1): 372.1718, found 372.1712.
S6

No comments:

Post a Comment