- Figure 1.
Important pharmacophore of 1,4-benzodiazepine nucleus.
- Scheme 1.
Synthesis of 2-amino-5-chloro-benzophenone derivatives (3a–3g)
2.3.3. 2-(4′-Chloroanilino)acetamido-5-chlorobenzophenone (3a)
IR (KBr cm−1): 3346 (Sec N–H str), 3100 (Aromatic C–H str), 2984 (Aliphatic C–H str), 1661 (C
O str), 1487 (Aromatic CC str), 1229 (C–N str) and 761 (C–Cl str) 1H NMR (DMSO-d6 1δ ppm): 4.19 (s, 2H, –COCH2N), 7.26–8.60 (m, 12H, Ar–H) and 11.46 (br s, 1H, –NHCOCH2–) Anal. Calcd. for C21H16 N2O2Cl2: C, 63.17; H, 4.04; N, 7.02; Found: C, 63.07; H, 4.02; N, 7.09.
1H NMR PREDICT
O str), 1487 (Aromatic CC str), 1229 (C–N str) and 761 (C–Cl str) 1H NMR (DMSO-d6 1δ ppm): 4.19 (s, 2H, –COCH2N), 7.26–8.60 (m, 12H, Ar–H) and 11.46 (br s, 1H, –NHCOCH2–) Anal. Calcd. for C21H16 N2O2Cl2: C, 63.17; H, 4.04; N, 7.02; Found: C, 63.07; H, 4.02; N, 7.09.1H NMR PREDICT
Original article
Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants
- Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, Nangal, Rupnagar, Punjab 140126, India
- Received 7 June 2011, Accepted 22 November 2011, Available online 3 December 2011
- Open Access funded by King Saud University
- Under a Creative Commons license
- Corresponding author. Tel.: +91 01887 221276, mobile: +91 9417513730; fax: +91 01887 221276 rksingh244@gmail.com
- 1 Present Address: Dept. of Pharmaceutical Chemistry, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, India.
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