(1S,3R)-3-Aminocyclopentanecarboxamide hydrochloride

(1S,3R)-3-Aminocyclopentanecarboxamide hydrochloride

Hydrogen chloride gas was bubbled through an ice-cooled solution of the amide from preparation 10 (438 mg, 1.92 mmol) in dichloromethane (50 ml) for 10 minutes, and the resulting suspension stirred at room temperature for 2 hours. The mixture was purged with nitrogen, then evaporated under reduced pressure. The residue was triturated with ether, to afford the title compound as a solid; 

¹H NMR (D₂O, 400 MHz) δ: 1.63-1.82 (m, 3H), 1.92-2.07 (m, 2H), 2.19 (m, 1H), 2.82 (m, 1H), 3.62 (m, 1H).