Ethyl 1-Ethyl-4-(4-(N-hydroxycarbamimidoyl)-1-methyl-1H-imidazol-5-yl)-1H-pyrrole-2-carboxylate

Ethyl 1-Ethyl-4-(4-(N-hydroxycarbamimidoyl)-1-methyl-1H-imidazol-5-yl)-1H-pyrrole-2-carboxylate, 12

hydroxyamidine 12 (58.2 g, 0.191 mol, 89% yield) as off-white plates (mp 226–229 °C): 

¹H NMR (400 MHz, DMSO-d₆) δ 9.15 (s, 1H), 7.67 (s, 1H), 7.50 (d, J = 1.8 Hz, 1H), 7.04 (d, J = 1.8 Hz, 1H), 5.33 (s, 2H), 4.32 (q, J = 7.1 Hz, 2H), 4.23 (q,J = 7.1 Hz, 2H), 1.34 (t, J = 7.1 Hz, 3H), 1.28 (t, J = 7.1 Hz, 3H);  

¹³C NMR (100 MHz, DMSO-d₆) δ 160.1, 148.0, 137.2, 130.9, 129.8, 123.8, 120.5, 118.8, 110.5, 59.5, 43.5, 32.2, 16.8, 14.3; 

HRMS-ESI (m/z) calcd for C₁₄H₂₀N₅O₃ [M + H]⁺ 306.1561, found 306.1551.

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 Qamishli, SYRIA

Al-Qamishli القامشلي Qamişlo
City
Al-Qamishli
Al-Qamishli Location in Syria
Coordinates: 37°03′N 41°13′E
Country	Syria
Governorate	Al Hasakah
District	Al-Qamishli
Nahiyah	Al-Qamishli
Founded	1926
Population (2004)Census
• Total	184,231
Time zone	EET (UTC+2)
• Summer (DST)	+3 (UTC)
Area code(s)	52

 

The President's street
 

Al-Qamishli streets during Christmas days

 

Al-Qamishli Granaries 

 
 

 
 

 

 

 
 

 



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N - (benzyloxy) - 2,2,2 - trichloroacetamide taught by Mom, Aunt

MOM can teach you organic spectroscopy..............so easy


N - (benzyloxy) - 2,2,2 - trichloroacetamide

Access to the Pyrroloindoline Core via [3 + 2] Annulation as well as the Application in the Synthetic Approach to (±)-Minfiensine

Wenzhi Ji, Licheng Yao, and Xuebin Liao^*

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University, Beijing 100084, China

Org. Lett., Article ASAP

DOI: 10.1021/acs.orglett.5b03421

Publication Date (Web): January 8, 2016

Copyright © 2016 American Chemical Society

*E-mail: liaoxuebin@mail.tsinghua.edu.cn.

 http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.5b03421

A [3 + 2] formal cycloaddition reaction using aza-oxyallyl cation as a synthetic synthon was developed to construct the pyrroloindololine core. With this novel method, a variety of C3-substituted indoles were readily converted into the corresponding pyrroloindoline analogues at room temperature in the mixed solvents. To further demonstrate the utility of this method, a synthetic approach to the total synthesis of (±)-minfiensine was developed in quite concise fashion.

http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.5b03421/suppl_file/ol5b03421_si_001.pdf





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Al-Qusayr

City in Syria

Al-Qusayr is a city in western Syria, administratively part of the Homs Governorate. It is located about 35 kilometers south of Homs and is situated in a mountainous area overlooking Syria's border with ... Wikipedia

 

 

 
 

 

 
 

The ubiquitous yummy Kabab

This shot … well, a Syrian school girl.

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3-[5-(4-Bromophenyl)-2,3-dihydro-1H-pyrrolizin-6-yl]-1,3-dihydro-2H-indol-2-one

 


3-[5-(4-Bromophenyl)-2,3-dihydro-1H-pyrrolizin-6-yl]-1,3-dihydro-2H-indol-2-one (7c):
brown powder, 17 %, mp 201-202 C;

1H NMR (200 MHz, DMSO-d6) δ: 10.42 (s, 1H, 1-NH),
7.53 (d, J=8.6 Hz, 2H, 3,5-CH (4-bromobenzoyl)), 7.21 (d, J=8.6 Hz, 2H, 2,6-CH (4
bromobenzoyl), 6.97-6.70 (m, 5H, oxindol), 5.18 (s, 1H, 7-CH), 4.44 (s, 1H, 3-CH), 4.16-3.70
(m, 2H, 3-CH2), 2.80-2.641 (m, 2H, 1-CH2), 2.44-2.28 (m, 2H, 2-CH2);

 



13C NMR (75 MHz,
DMSO-d6) δ: 178.86 (2-CO), 141.81, 138.34, 135.49, 131.38, 129.47, 129.32, 127.24, 127.05,
124.30, 121.24, 120.21, 116.81, 109.69, 99.23, 46.26, 45.33, 27.31, 24.43.

 
Anal. calcd. for
C21H17BrN2O (393.28):C 64.13; H 4.36; N 7.12; Found: C 63.90; H 4.39; N 7.18.






 MADAYA,  SYRIA

 

 
 

 

 

 
 

Madaya, Syria

Town in Syria

Madaya is a small mountainous town in Syria, located at an altitude of 1,400 metres. It is a well known holiday resort. It is located about 40 kilometres northwest of Damascus in the Rif Dimashq Governorate and is home to Lake Barada. Wikipedia

 


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