1-Methyl-3-methylenepyrrolidin-2-one

paper

Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes

Mingyang Fu, Long Chen, Yongpeng Jiang, Zhong-Xing Jiang^*, and Zhigang Yang^*

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China

Org. Lett., Article ASAP

DOI: 10.1021/acs.orglett.5b03080

Publication Date (Web): January 11, 2016

Copyright © 2016 American Chemical Society

*E-mail: zxjiang@whu.edu.cn., *E-mail: zgyang@whu.edu.cn.

A highly practical copper-catalyzed intermolecular halotrifluoromethylation of alkenes has been developed under mild reaction conditions. A variety of Cl/Br-containing trifluoromethyl derivatives were directly synthesized from a wide range of alkenes, including electron-deficient and unactivated alkenes.

 http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b03080

 see...........http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.5b03080/suppl_file/ol5b03080_si_002.pdf









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COOK ISLANDS

• Cook Islands – Wikipedia, the free encyclopedia

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  The Cook Islands‘ defence and foreign affairs are the responsibility of New Zealand, which is exercised in consultation with the Cook Islands. In recent times, the …
  

  ‎Rarotonga – ‎Avarua – ‎Cook Islanders – ‎Aitutaki
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MONTELUKAST IMPURITY 1

 1H NMR (400 MHz, DMSO): δ 8.38 (d, J = 8.8 Hz, 1H), 8.10–7.89 (m, 5H), 7.66–7.56 (m, 3H), 7.46–7.22 (m, 6H), 3.56 (s, 2H). 

13C NMR (100 MHz, DMSO): δ 182.1, 157.0, 148.1, 145.4, 144.8, 136.5, 135.9, 134.2, 129.7, 129.3, 128.1, 127.9, 127.3, 127.2, 127.1, 126.5, 125.5, 125.5, 124.4, 121.1, 120.4, 106.3, 34.0; 

HRMS (ESI) calcd for [M + H, C27H19ClNO2]+: 424.1104, Found 424.1110.

TEHRAN, IRAN

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N - (benzyloxy) - 2,2,2 - trichloroacetamide taught by Mom, Aunt

MOM can teach you organic spectroscopy..............so easy


N - (benzyloxy) - 2,2,2 - trichloroacetamide

Access to the Pyrroloindoline Core via [3 + 2] Annulation as well as the Application in the Synthetic Approach to (±)-Minfiensine

Wenzhi Ji, Licheng Yao, and Xuebin Liao^*

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University, Beijing 100084, China

Org. Lett., Article ASAP

DOI: 10.1021/acs.orglett.5b03421

Publication Date (Web): January 8, 2016

Copyright © 2016 American Chemical Society

*E-mail: liaoxuebin@mail.tsinghua.edu.cn.

 http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.5b03421

A [3 + 2] formal cycloaddition reaction using aza-oxyallyl cation as a synthetic synthon was developed to construct the pyrroloindololine core. With this novel method, a variety of C3-substituted indoles were readily converted into the corresponding pyrroloindoline analogues at room temperature in the mixed solvents. To further demonstrate the utility of this method, a synthetic approach to the total synthesis of (±)-minfiensine was developed in quite concise fashion.

http://pubs.acs.org/doi/suppl/10.1021/acs.orglett.5b03421/suppl_file/ol5b03421_si_001.pdf





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Al-Qusayr

City in Syria

Al-Qusayr is a city in western Syria, administratively part of the Homs Governorate. It is located about 35 kilometers south of Homs and is situated in a mountainous area overlooking Syria's border with ... Wikipedia

 

 

 
 

 

 
 

The ubiquitous yummy Kabab

This shot … well, a Syrian school girl.

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