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Saturday 17 January 2015

4-(trans-2-((R)-2-methylpiperazine-1 -carbonyl)cyclopropyl)benzamide

4-(trans-2-((R)-2-methylpiperazine-1 -carbonyl)cyclopropyl)benzamide
Figure imgf000037_0001
Intermediate B (849 mg, 2.19 mmol) was dissolved in DCM (10.0 mL). TFA
(5.00 mL) was added and the reaction mixture stirred at rt for 30 min. Volatiles were evaporated under reduced pressure to give a yellow gum. The crude material was used in the next step without purification. 

1H NMR (400 MHz, CD3OD) δ ppm 1 .33 (d, J=7.03 Hz, 3H) 1 .37-1 .52 (m, 3 H) 1 .65 (br. s., 1 H) 2.26-2.39 (m, 1 H) 2.51 (br. s., 1 H ) 3.1 1 (br. s., 1 H) 3.21 -3.45 (m, 4H) 7.27 (d, J=8.20 Hz, 2H) 7.81 (d, J=8.20 Hz, 2 H).

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