DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Thursday, 1 January 2015


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To a stirred solution of 12.6 g (75.6 mmol) of chloral hydrate in 168 mL water was added the following: 180 g (1.27 mole) sodium sulfate; 7.67 g (62.4 mmol) 4-methoxyaniline in 6 mL of concentrated HC1 and 42 mL of water; and 15.4 g (224 mmol) of hydroxylamine hydrochlori.de in 70 mL of water. The mixture was heated slowly to 100°C and kept at that temperature for 1 h. The mixture was cooled to room temperature, filtered and the precipitate washed with water and dried to give 81% yield of the anilide: Η MR (300 MHz, DMSO-d6) δ 12.15 (s, IH) 10.1 (s, IH) 7.65 (s, IH) 7.6 (d, 2H) 6.95 (d, 2H) 3.75 (s, 3H). The crude anilide (10.8 g, 61 mmol) was added to 27 mL of concentrated sulfuric acid at 50°C, heated at 65°C for 1 h, cooled to room temperature, and poured into 300 mL of ice. The solids were filtered and dried in vacuo over P2O5. The crude isatin was dissolved in boiling CH2C12 with 2% N-methylpyrrolidone and applied to a silica gel column. The product was eluted using a CH2Cl2:MeOH gradient 100% CH2C12 to (9:1) CH2Cl2:MeOH. 5-Methoxyisatin was obtained in 12% yield overall: mp 168-172°C;

 *H NMR (300 MHz, DMSO-d6) δ 10.85 (s, IH) 7.17-7.24 (m, IH) 7.1 (d, IH) 6.87 (d, IH) 3.75 (s, 3H); 

MS (M+CH4CN)+ 158.


Map of vietnam country.

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 dalat city



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