Preparation of 4-(4'-methoxyphenyl)-3-buten-2-one (Product A)A p-anisaldehyde (1.2mL, 10mmol) is prepared in acetone (15mL) in a 100mL round bottom flask. A magnetic flea is then added and the flask is clamped over a magnetic stirrer. A potassium hydroxide (1.0 g) solution in water (20mL) is prepared in a separate beaker and added gradually to the mixture in the flask with continuous stirring for 20 minutes.
Now, around 40mL of water is added to the reaction mixture to ascertain the precipitation of all products. The resulting solid is filtered by vacuum filtration, followed by water washing. The solid is then dried and recrystalized from ethanol (Figure 1).