Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction

An efficient and highly eco-friendly synthesis of diverse and functionalized 2-pyridone derivatives in good yield via the thermal multicomponent reaction of 4-oxo-4H-chromene-3-carbaldehydes with 1,3-diketoesters and anilines or primary aliphatic amines under catalyst- and solvent-free conditions is described. This reaction proceeds via domino Knoevenagel condensation/Michael addition/ring opening/ring closure reactions.

Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction
Green Chem., 2015, 17,4579-4586
DOI: 10.1039/C5GC01526J, Paper
Tej Narayan Poudel, Yong Rok Lee, Sung Hong Kim
http://pubs.rsc.org/en/Content/ArticleLanding/2015/GC/C5GC01526J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract
An eco-friendly protocol for diverse and functionalized 2-pyridone derivatives via a multicomponent reaction under catalyst- and solvent-free conditions has been developed.



 












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