4-METHOXYPHENYL BORONIC ACID

4-METHOXYPHENYL BORONIC ACID

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The heterogeneous palladium-catalyzed Suzuki reactions between model aryl bromides (4-bromoanisole, 4-bromoaniline, 4-amino-2-bromopyridine, and 2-bromopyridine) and phenylboronic acid have been successfully conducted in water with no added ligand at the 100 mL scale using 20–40 mmol of aryl bromide. The product yields associated with these substrates were optimized, and key reaction parameters affecting the yields were identified. The results clearly indicate that the reaction parameters necessary to achieve high yields are substrate-dependent. In addition, it is demonstrated that aqueous Suzuki reactions of substrates containing basic nitrogen centers can produce quantitative yields of desired products in the absence of added ligand.

Palladium-Catalyzed Suzuki Reactions in Water with No Added Ligand: Effects of Reaction Scale, Temperature, pH of Aqueous Phase, and Substrate Structure

Zhao Li^†, Carol Gelbaum^†, William L. HeanerIV^†, Jason Fisk^§, Arvind Jaganathan^§, Bruce Holden^§, Pamela Pollet^†, and Charles L. Liotta^*†‡

^† School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

^‡ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

^§ The Dow Chemical Company, Midland, Michigan 48674, United States

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.6b00180

*E-mail: charles.liotta@chemistry.gatech.edu.

http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00180

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• Supporting Info

JUBA, SOUTH SUDAN

Juba

Capital of South Sudan

Juba /ˈdʒuːbə/ is the capital and largest city of the Republic of South Sudan. It also serves as the capital of Central Equatoria, one of the ten states of South Sudan. Wikipedia

What to eat in Juba, food in South Sudan

In Juba there are many places to eat. Most hotels have restaurants open late. There are also inexpensive options for eating on the streets.

There are scattered around the city a series of restaurants where you can find the best food in Juba. Here in these places and with very little money you can eat traditional food of South Sudan and contact with local people in a familiar environment.

Throughout the city there are small handcarts with pineapple that come from Uganda. You can also find small bean cakes and pies on street vendors near the Konya Konya market.

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